NCT05642156Recruiting
Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis
Source: ClinicalTrials.gov · Last updated 8 Oct 2026
Brief summary (registry, in English)
Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients. Intradialytic hypotension (IDH), which is an independent risk factor for mortality, occurs in up to 20% of hemodialysis session and may lead to myocardial stunning and cerebral ischemia resulting in increased white matter lesions, gastrointestinal ischemia and shunt vessel thrombosis. Due to the deleterious effects of IDH during HD, preventive measurements such as limiting interdialytic weight gain are recommended, but frequently fluid and salt restriction are not adhered to, thus increasing dialysis time or frequency of treatments is a common strategy in those patients.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 32 (estimated)
- First submitted
- 17 Nov 2022
- Start date
- 2 Nov 2022
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Medical University of Graz
- Diseases
- Chronic kidney disease
- NCT number
- NCT05642156
What you commit to
- Study type: Interventional
- Planned participants: 32
- From 2 Nov 2022 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients treated with hemodiafiltration
- Patients treated with medium cut-off membranes (Theranova, Baxter)
Lab values
- Patients with recurrent severe hyperkalemia after the short interdialytic interval (K+ concentration \> 6.0 mmol/L, requiring more than 2 hours of dialysis to ameliorate the post-dialytic shift from other compartments.
Age
- Women of childbearing age not using contraception
Other
- No informed consent was obtained
- Patients with a pacemaker or implanted medical device that prevents compliance with study regulations
Who the study is looking for
- Written consent of the participant after being informed
- At least 18 years of age
- End stage kidney disease patient undergoing hemodialysis
- Dry weight stable for a minimum of one month
- Interdialytic weight gain of \>2 liters in the short interdialytic interval
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of Graz Coordinator of this site? Confirm its status | Graz | Austria | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.