NCT05645861Active, not recruiting
MAnagement of Systolic Blood Pressure During Thrombectomy by Endovascular Route for Acute Ischaemic STROKE
MAnagement of Systolic Blood Pressure During Thrombectomy by Endovascular Route for Acute Ischaemic STROKE: the MASTERSTROKE Trial
Source: ClinicalTrials.gov · Last updated 5 Jan 2026
Brief summary (registry, in English)
Stroke is the third most common cause of death in New Zealand and is one of the leading causes of long-term disability at all ages. A life-saving clot retrieval procedure can save lives and prevent disability of patients with ischaemic stroke who get to hospital in time. In New Zealand, 90% of clot retrieval procedures are performed under general anaesthesia. Many anaesthetic drugs can affect blood pressure (BP) and blood flow within the brain. Increasing BP during the procedure could provide additional benefits in this devastating disease. A large trial is needed to investigate BP management during clot retrieval.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 550 (estimated)
- First submitted
- 30 Nov 2022
- Start date
- 28 Nov 2019
- Primary completion date
- 31 Jan 2026
- Lead sponsor
- Auckland City Hospital
- Diseases
- Stroke
- NCT number
- NCT05645861
What you commit to
- Study type: Interventional
- Planned participants: 550
- From 28 Nov 2019 to the primary completion date, 31 Jan 2026
- 6 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Rescue"' procedures eg acute ischaemic stroke associated with major medical procedures such as coronary artery stenting and coronary artery bypass
- pre-stroke mRS\>=3
- not having GA
- terminal illness with expected survival \<1 year
- pregnancy
- cardiovascular conditions where BP targeting will be contra-indicated
- unable to participate in 3-month follow up
Who the study is looking for
- Patients diagnosed with anterior circulation stroke (ICA or proximal M1 or M2 segment of MCA) treated with ECR within 6 hrs of stroke onset and ECR patients presenting within 6-24 hours and favourable penumbra on perfusion scanning (see criteria 1-3).
- Additional criteria in the 6 to 24-hour window.
- 'wake up' stroke; CT with no (or at most minimal) acute infarction or
- patient 80 years or older (NIHSS of 10 and infarct volume less than 21 ml on DWI or CT perfusion-CBF)
- patient less than 80 years (NIHSS of 10 and infarct volume less than 31 ml on DWI or CT perfusion-CBF NIHSS of 20 and infarct volume less than 51 ml on DWI or CT perfusion-CBF).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Gold Coast University Hospital Coordinator of this site? Confirm its status | Southport | Australia | Unknown status |
| Royal North Shore Hospital Coordinator of this site? Confirm its status | Sydney | Australia | Unknown status |
| Metro South Hospital and Health Service via the Princess Alexandra Hospital Coordinator of this site? Confirm its status | Woolloongabba | Australia | Unknown status |
| Auckland City Hopsital Coordinator of this site? Confirm its status | Auckland | New Zealand | Unknown status |
| Christchurch Hospital Coordinator of this site? Confirm its status | Christchurch | New Zealand | Unknown status |
| Wellington Regional Hospital Coordinator of this site? Confirm its status | Newton | New Zealand | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.