NCT05649384Active, not recruiting
Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)
PRospective Evaluation of the European Society of Cardiology 0/1-hour Algorithm's Safety and Efficacy for Triage of Patients With Suspected Myocardial Infarction (PRESC1SE-MI)
Source: ClinicalTrials.gov · Last updated 17 Sept 2026
Brief summary (registry, in English)
The PRESC1SE-MI study compares two algorithms for triage of patients presenting with chest pain and symptoms of heart attack (myocardial infarction) to the emergency department. Both algorithms are recommended by the European Society of Cardiology: the 0/3-hour algorithm and the 0/1-hour algorithm. Currently, most emergency departments worldwide use the 0/3-hour troponin algorithm. Cardiac troponin (cTn) is a heart-specific biomarker which indicates damage of the heart muscle and which increases after a heart attack. In the 0/3-hour algorithm, the amount of troponin in the bloodstream is measured with a high-sensitivity assay at admission and 3 hours thereafter. Likewise, the 0/1-hour algorithm means that the blood sample in which the troponin is measured is collected at admission and 1 hour later. Since recent clinical studies suggest that the 0/1-hour algorithm is superior to the 0/3-hour algorithm, many hospitals consider switching to the 0/1-hour algorithm. The aim of this study is to assess how feasible the time-saving 0/1-hour algorithm would be in reality and whether it provides the same accuracy and safety in the diagnosis of myocardial infarction as the current practice the 0/3-hour algorithm.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 64374 (estimated)
- First submitted
- 14 Nov 2022
- Start date
- 1 Dec 2020
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- University Hospital, Basel, Switzerland
- Diseases
- Coronary artery disease
- NCT number
- NCT05649384
What you commit to
- Study type: Interventional
- Planned participants: 64374
- From 1 Dec 2020 to the primary completion date, 31 Dec 2027
- 20 sites in 11 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Terminal kidney failure requiring dialysis
- Cardiac arrest
Other
- Cardiogenic shock
Who the study is looking for
- Patients aged 18 and above
- Presentation with acute non-traumatic acute chest pain to the emergency department
- Suspicion of acute myocardial infarction
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (20)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vienna General Hospital (AKH Wien) Coordinator of this site? Confirm its status | Vienna | Austria | Unknown status |
| St Andrew's War Memorial Hospital Brisbane Coordinator of this site? Confirm its status | Brisbane | Australia | Unknown status |
| Kantonsspital Aarau Coordinator of this site? Confirm its status | Aarau | Switzerland | Unknown status |
| St. Claraspital Coordinator of this site? Confirm its status | Basel | Switzerland | Unknown status |
| Kantonsspital Luzern Coordinator of this site? Confirm its status | Lucerne | Switzerland | Unknown status |
| University Hospital Zurich Coordinator of this site? Confirm its status | Zurich | Switzerland | Unknown status |
| Hospital Clinic Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| University Hospital Ramon y Cajal Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| University Hospital October 12 Madrid Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Hospital Clinico Universitario Valencia Coordinator of this site? Confirm its status | Valencia | Spain | Unknown status |
| University Central Hospital Helsinki Coordinator of this site? Confirm its status | Helsinki | Finland | Unknown status |
| Royal London Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Royal Cornwall Hospitals Treliske Coordinator of this site? Confirm its status | Truro | United Kingdom | Unknown status |
| Attikon General Hospital Athens Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| Careggi University Hospital Florence Coordinator of this site? Confirm its status | Florence | Italy | Unknown status |
| Azienda Ospedaliera San Giovanni Addolorata Coordinator of this site? Confirm its status | Roma | Italy | Unknown status |
| Hospital Città della Salute e della Scienza di Torino Coordinator of this site? Confirm its status | Torino | Italy | Unknown status |
| Konkuk University Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Emergency Institute for Cardiovascular Diseases C.C. Iliescu Coordinator of this site? Confirm its status | Bucharest | Romania | Unknown status |
| Baylor St. Luke's Medical Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.