NCT05649657Completed
Effect of Lifestyle Intervention in Patients With Chronic Kidney Disease on Fitness and Immune Function
Source: ClinicalTrials.gov · Last updated 19 Aug 2025
Brief summary (registry, in English)
To assess the efficacy of a 6-month lifestyle intervention in patients with end-stage renal disease(ESRD), we plan to conduct a self-controlled clinical trial. 34 participants receiving chronic HD will be enrolled. Each participant will go through three phases: 3-month control, 6-month intervention, and 3-month maintenance. No intervention will be performed in the control and maintenance phases. The lifestyle intervention will comprise care from a multidisciplinary team, including a nephrologist, nurse practitioner, physiatrist, and dietitian. The exercise training component is an in-hospital supervised training 2\~3 times weekly for 6 months. Cyclic aerobic and resistance training will be performed. Assessment will be performed every three months and 5 times in total, including cardiopulmonary exercise testing, isokinetic quadriceps strength testing, hand grip strength, body composition analysis, Chinese Kidney Disease and Quality of Life questionnaire, self-recorded physical activity, and Mini Nutritional Assessment. The aim of this study is to assess the efficacy of a lifestyle intervention in patients with chronic kidney disease (CKD) on physical fitness, quality of life, and immunity. It is hypothesized that the lifestyle intervention will elicit a significant benefit in the aforementioned parameters and will last until the maintenance phase.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 34 (actual)
- First submitted
- 7 Nov 2022
- Start date
- 1 Jul 2020
- Primary completion date
- 28 Feb 2025
- Lead sponsor
- Chang Gung Memorial Hospital
- Diseases
- Chronic kidney disease
- NCT number
- NCT05649657
What you commit to
- Study type: Interventional
- Participants enrolled: 34
- From 1 Jul 2020 to the primary completion date, 28 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- comorbid medical, physical, and mental conditions that contraindicate exercise
- unstable cardiac conditions (eg, unstable angina, heart failure or symptomatic severe aortic stenosis, etc.)
- disabling orthopedic and neuromuscular diseases
Other
- occurrence of hyperkalemia in the past 3 months
Who the study is looking for
- patients who are on HD for longer than 6 months
- under the permission of their nephrologist
- adequately dialyzed (most recent Kt/V \> 1.2) and stable during dialysis in the past 3 months
Age in the registry: 20 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chang Gung Memorial Hospital Coordinator of this site? Confirm its status | Taoyuan | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.