NCT05649800Recruiting
Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project
Evaluating the Feasibility of Remote Haemodynamic Monitoring in a Cohort of Multi-ethnic Chronic Stroke Patients Using a Novel User Interface and Artificial Intelligence Algorithms
Source: ClinicalTrials.gov · Last updated 1 Dec 2025
Brief summary (registry, in English)
The goal of this observational study is to determine the feasibility of using integrated Transcranial Doppler Ultrasonography or Near Infrared Spectroscopy to detect changes in cerebral autoregulation and neurovascular coupling in healthy, stroke, dementia, depression and delirium populations. We also aim to: * Determine the optimal stimulus for neurovascular coupling * To derive sample size estimates for a future study * To develop a multilevel, multivariate model that can be applied to future datasets
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 140 (estimated)
- First submitted
- 22 Nov 2022
- Start date
- 17 Mar 2023
- Primary completion date
- 26 Nov 2025
- Lead sponsor
- University of Leicester
- Diseases
- Stroke
- NCT number
- NCT05649800
What you commit to
- Study type: Observational
- Planned participants: 140
- From 17 Mar 2023 to the primary completion date, 26 Nov 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Inclusion Criteria:
- Healthy adults aged over 65 years, free from medical comorbidities or medications that can adversely affect cognitive function or cerebral haemodynamics;
- Stable, well controlled comorbidities (e.g. hypertension);
- A diagnosis of dementia (major neurocognitive disorder), depression, or delirium, according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V) criteria;
- Participants on or off anti-dementia drug therapy (acetylcholinesterase inhibitors, NMDA receptor antagonists), and antidepressants;
- A diagnosis of ischaemic (IS) or haemorrhagic (ICH) stroke according to clinical and/or radiological findings, within 72 hours of symptom onset
- Exclusion Criteria:
- Poorly controlled medical comorbidities affecting cerebral haemodynamics or cognitive function (e.g., heart failure, hypertension, type two diabetes);
- Clinically unstable or too unwell to cooperate with the study protocol;
- Lacks capacity or personal consultee to consent to the study.
Age in the registry: 65 years to - · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospitals of Leicester NHS Trust Coordinator of this site? Confirm its status | Leicester | United Kingdom | Recruiting |
| Leicestershire Partnership Trust Coordinator of this site? Confirm its status | Leicester | United Kingdom | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.