NCT05651529Completed
Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?
Does Oral Intake of Beta-hydroxybutyrate Decrease Left Ventricular End-systolic Volume at Cardiac Magnetic Resonance in Patients With Heart Failure Compared to Carbohydrate Placebo?
Source: ClinicalTrials.gov · Last updated 7 Jan 2026
Brief summary (registry, in English)
Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 20 (actual)
- First submitted
- 29 Nov 2022
- Start date
- 16 Dec 2022
- Primary completion date
- 16 Dec 2025
- Lead sponsor
- Université de Sherbrooke
- Diseases
- Heart failure
- NCT number
- NCT05651529
What you commit to
- Study type: Interventional
- Participants enrolled: 20
- From 16 Dec 2022 to the primary completion date, 16 Dec 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients treated with any SGLT2i;
Other illness
- Diabetes
- Chronic kidney disease
- Acute coronary syndrome in the last 3 months;
- Medical condition that causes malabsorption of the test material;
Other
- Use of parenteral inotropic agents;
- Persistent or permanent atrial fibrillation or atrial flutter;
- Presence of pacemaker or defibrillator;
- Under ketogenic diet, or using exogenous ketone supplements
- Use of nicotinamide adenine dinucleotide (NAD) precursor supplements
Who the study is looking for
- Patients with heart failure with left ventricle ejection fraction of 40%
- Heart failure of ischemic or dilated etiology
- Ambulatory patient with a NYHA functional class of II-III;
- Stable symptoms and no change in medical therapy in the last month.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre Hospitalier Universitaire de Sherbrooke, departement de médecine Coordinator of this site? Confirm its status | Sherbrooke | Canada | Unknown status |
| Centre Hospitalier Universitaire de Sherbrooke, departement de cardiologie Coordinator of this site? Confirm its status | Sherbrooke | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.