NCT05653986Completed
An Observational Study to Assess Change in Disease Activity When Ubrogepant Tablets Are Combined With Atogepant Tablets to Treat Migraine in Adult Participants
A Prospective, Observational Diary Study to Evaluate the Real-World Effectiveness of the Acute Treatment of Migraine With Ubrogepant, When Used in Combination With Atogepant for Prevention
Source: ClinicalTrials.gov · Last updated 3 Jun 2026
Brief summary (registry, in English)
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will how effective the combination use of ubrogepant and atogepant is in treating adult participants with migraine. Change in migraine activity will be assessed. Urogepant (Ubrelvy) and Atogepant (Qulipta) are approved drugs for treatment of migraine in adults in the US. Approximately 432 adult participants who are prescribed Ubrogepant and atogepant by their doctors will be enrolled in this study in the United States. Participants will receive ubrogepant oral tablets and atogepant oral tablets as prescribed by their physician. Participants will be followed for 30 days. There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 391 (actual)
- First submitted
- 14 Dec 2022
- Start date
- 18 Dec 2022
- Primary completion date
- 5 Aug 2024
- Lead sponsor
- AbbVie
- Diseases
- Migraine
- NCT number
- NCT05653986
What you commit to
- Study type: Observational
- Participants enrolled: 391
- From 18 Dec 2022 to the primary completion date, 5 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Report currently taking Rimegepant (Nurtec®) for migraine treatment (acute or preventive).
- Report currently taking any of the anti-CGRP mAbs for preventive treatment of migraine:
- Erenumab (Aimovig®)
- Galcanezumab (Emgality®)
- Fremanezumab (Ajovy®)
- Eptinezumab (Vyepti®)
Who the study is looking for
- Reports meeting migraine diagnostic criteria consistent with International Classification of Headache Disorders (ICHD) (i.e., they report symptoms accompanying their headaches that meet migraine criteria22 at screening).
- Currently using ubrogepant for acute treatment of migraine.
- Experienced at least 3 migraine attacks in the last 30 days.
- Currently taking atogepant for preventive treatment of migraine and has been taking atogepant, at the same dose, for at least 30 days.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Montefiore/Albert Einstein /ID# 252243 Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.