NCT05663008Recruiting
Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis
Source: ClinicalTrials.gov · Last updated 23 Dec 2022 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Motor neuron disease (MND) or ALS is a nervous system disease. ALS leads to a loss of movement ability that eventually leads to death. At the moment, there is no known treatment for ALS. Early diagnosis in individuals improves clinical care and facilitates timely entry into clinical trials. However, current methods for diagnosis are primarily clinical, and to date, no cost-effective biomarkers have been developed. Our objective is to identify a robust non-invasive neurophysiological-based system that can be used both as a biomarker of disease onset, and a measurement of progression using quantitative EEG and surface EMG (bipolar and high-density). The investigators postulate that analysing the joint recordings of EEG and EMG (bipolar or high-density) can give measures that better distinguish healthy people and ALS patient subgroups and that the findings can be developed as biomarkers of early diagnosis and disease progression.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 2 Dec 2022
- Start date
- 1 Oct 2015
- Primary completion date
- 30 Jan 2027
- Lead sponsor
- University of Dublin, Trinity College
- NCT number
- NCT05663008
What you commit to
- Study type: Observational
- Planned participants: 400
- From 1 Oct 2015 to the primary completion date, 30 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of neuromuscular
- neurological or active psychiatric disease disease
- history of reaction or allergy to recording environments, equipment and the recording gels.
- Patients:
- the presence of active psychiatric disease
- any medical condition associated with severe neuropathy (e.g. poorly controlled diabetes).
- History of reaction or allergy to recording environments, equipment and the recording gels.
Other
- Healthy Controls:
Who the study is looking for
- Healthy Volunteers:
- age and gender-matched to patient groups
- the intact physical ability to take part in the experiment.
- Patients:
- Diagnosis of ALS, PLS, PMA, SMA, Polio or MS
- capable of providing informed consent.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Academic Unit of Neurology, Trinity College Dublin, The University of Dublin Coordinator of this site? Confirm its status | Dublin | Ireland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.