NCT05684172CompletedPhase 2/3
Intra-arterial TNK Following Endovascular Thrombectomy in Patients With Large Vessel Occlusion of Posterior Circulation
Trial of Intra-arterial Tenecteplase Following Successful Endovascular Thrombectomy on Safety and Efficacy in Patients With Large Vessel Occlusion of Posterior Circulation - a Multicenter Randomized Clinical Trial (ATTENTION IA)
Source: ClinicalTrials.gov · Last updated 11 Apr 2024
Brief summary (registry, in English)
Rationale: Recently, one prospective multicenter RCT reported a potential beneficial effect of intra-arterial alteplase following successful endovascular thrombectomy (EVT) in patients with an acute intracranial large vessel occlusion. In 2018, another prospective multicenter RCT supported the superiority of tenecteplase over alteplase in ischemic stroke patients with large vessel occlusion. Objective: To assess the effect of EVT in addition to intra-arterial tenecteplase compared to EVT alone, in patients with large vessel occlusion of posterior circulation, on functional and safety outcomes. Study design: This is a parallel group, randomized clinical trial of EVT with IA-TNK versus EVT. The trial has observer blind assessment of the primary outcome and of neuro-imaging at baseline and follow-up. Study population: Patients with acute intracranial large vessel occlusion of posterior circulation and an eTICI 2b-3 after EVT. Main study parameters/outcomes: The primary effect parameter will be excellent functional status at day 90 defined as a modified Rankin Score (mRS) of 0-1. The estimate will be adjusted for the known prognostic variables age, pre-stroke mRS, time from onset to randomization, stroke severity (NIHSS) and collaterals and adjusted and unadjusted estimates with corresponding 95% confidence intervals will be reported.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 208 (actual)
- First submitted
- 5 Jan 2023
- Start date
- Jan 2023
- Primary completion date
- Aug 2023
- Lead sponsor
- The First Affiliated Hospital of University of Science and Technology of China
- Diseases
- Stroke
- NCT number
- NCT05684172
What you commit to
- Study type: Interventional · Phase 2/3
- Participants enrolled: 208
- From Jan 2023 to the primary completion date, Aug 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindication to Intravenous Thrombolysis (except time to therapy);
- Participation in other investigational drug or device clinical trials;
- Systolic pressure \>185 mmHg or diastolic pressure \>110 mmHg, and cannot be controlled by antihypertensive drugs;
- Major surgery or severe trauma within the last 2 weeks.
- History of prior intracranial hemorrhage.
Other illness
- Severe contrast allergy or absolute contraindication to iodinated contrast;
- Clinical presentation suggests a subarachnoid hemorrhage, even if initial CT or MRI scan is normal;
- CT/MR shows intracranial hemorrhage;
- Ischemic stroke within 3 months;
Lab values
- Pregnancy; if a woman is of childbearing potential a urine or serum beta HCG test is positive;
- Known genetic or acquired bleeding diathesis, lack of anticoagulant factors, or oral anticoagulant drugs and INR \> 1.7, or treated with direct oral anticoagulant agents in the prior 48 hours;
- platelets \<100 000/mm3, aPTT \>40 s, or PT \>15 s; Blood glucose \< 2.7 or \>22.2 mmol/L;
- Severe renal Failure as defined by a serum creatinine \> 3.0 mg/dl (or 265.2 μmol/l) or glomerular Filtration Rate \[GFR\] \< 30, or patient requires hemodialysis or peritoneal dialysis;
Other
- Pre-existing dependency with mRS \>1;
- Complete clinical recovery in the angiography suite by end of EVT procedure;
- Suspicion of aortic dissection;
- Presumed vasculitis or septic embolization;
- Life expectancy \< 1 year;
- Patients that cannot complete 90-day follow-up (e.g. no fixed residence, overseas patients, etc.)；
- Severe head trauma within 3 months;
Who the study is looking for
- Acute ischemic stroke patients with symptomatic intracranial large vessel occlusion (LVO) in the intracranial vertebral artery, basilar artery, or the P1 segment of the posterior cerebral artery.
- Treated with endovascular thrombectomy (EVT) resulting in an eTICI score 2b50/3 at end of the procedure.
- Age of 18 years or older;
- National Institutes of Health Stroke Scale (NIHSS) score on admission≥6;
- Posterior Circulation ASPECTS ≥ 6 on CT/CTA-Source Images/MRI-DWI.
- Time from estimated time of basilar artery occlusion to randomization\<24 hours;
- Written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine Coordinator of this site? Confirm its status | Hefei | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.