NCT05690737Completed
Tai Chi for the Prophylaxis of Episodic Migraine: the Efficacy Examination and Mechanism Exploration
A Randomized Controlled Trail to Examine the Efficacy of Tai Chi for the Prophylaxis of Episodic Migraine Compared With Standard Prophylactic Medication in Chinese Women and a Pre-post Neuroimaging and Laboratory-based Study to Explore the Mechanism of Tai Chi's Intervention Effect
Source: ClinicalTrials.gov · Last updated 10 Sept 2026
Brief summary (registry, in English)
The proposed study aims to examine the clinical efficacy of 24-week Tai Chi training in the prophylaxis of episodic migraine comparing with standard prophylactic medication in Hong Kong Chinese women, and to explore the mechanism of Tai Chi's intervention effect by examining the associations of changes in migraine features with neurovascular and neuroinflammation variations.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 220 (actual)
- First submitted
- 10 Jan 2023
- Start date
- 11 Sept 2023
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- The Hong Kong Polytechnic University
- Diseases
- Migraine
- NCT number
- NCT05690737
What you commit to
- Study type: Interventional
- Participants enrolled: 220
- From 11 Sept 2023 to the primary completion date, 30 Jun 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Experience with Tai Chi or other body-mind exercises (yoga, biofeedback, medication, etc.) after diagnosis of migraine.
- Undergoing other alternative therapeutic treatments during recruitment period, or received other alternative therapeutic treatments in the past 12 weeks.
- Pregnancy, lactation period, or currently using contraceptives.
- Drug abuse, take antipsychotic or antidepressant drugs, or take analgesics for other chronic pain more than 3 days a month in the past 12 weeks.
Other illness
- Secondary headache and other neurological disease.
- Epilepsy, or have a psychiatric disease.
Other
- Severe migraine attacks with disabilities that cannot perform moderate intensity physical activity.
- More than 5 days of non-migrainous headache per month.
- Use of pharmacological prophylactic treatment for migraine in the past 12 weeks.
Who the study is looking for
- Chinese woman, aged 18-65 years.
- Have a clinical diagnosis of episodic migraine (migraine with less than 15 attacks per month) with or without aura according to the International Classification of Headache Disorders, 3rd edition (ICHD-3).
- First migraine attack before the age of 45 years.
- Between two and six migraine attacks in one month.
- At least one of the following migraine characteristics is met: nausea, vomiting, photophobia, or phonophobia.
- Duration of migraine attacks is 2-72 h without acute medication or at least 1 h with acute medication.
- Able to undertake designated level of Tai Chi exercise.
- Live in Hong Kong.
Age in the registry: 18 years to 65 years · Sex: Female · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Hong Kong Polytechnic University Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Unknown status |
| The Hong Kong Polytechnic University Coordinator of this site? Confirm its status | Hung Hom | Hong Kong SAR China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.