NCT05693246Completed
Effect of Perioperative Use of Glycopyrrolate on Lung Function in Patients Under General Anesthesia
Effect of Perioperative Use of Glycopyrrolate on Lung Function in Elderly Patients Undergoing Laparoscopic Surgery For Gastrointestinal Cancer
Source: ClinicalTrials.gov · Last updated 8 May 2026
Brief summary (registry, in English)
Gastrointestinal tumor is one of the highest incidence of malignant tumors in our country, with the incidence increasing year by year. Laparoscopic gastrointestinal surgery ,due to having less bleeding ,small trauma ,Rapid recovery ,has become the main means for the treatment of gastrointestinal surgery. Under general anesthesia, mechanical ventilation can lead to repeated mechanical dilation of alveoli, which can lead to mechanical injury of alveolar epithelium, reduce lung compliance, affect lung function, and increase postoperative complications and hospital stay of patients. Glycopyrrolate acts selectively on M1 and M3 receptors, and is 3-5 times more selective to M3 and M1 receptors than M2 receptors. Therefore, as preoperative medication for elderly patients, it has less effect on the cardiovascular system and can stabilize the heart rate,compared with atropine.However, its influence on the respiratory system in the field of anesthesia is only limited to the study of inhibiting glandular secretion at present, and there are no clear reports on the study of respiratory mechanics. The objective of this study was to evaluate the effect of glycopyrrolate on oxygenation index in elderly patients undergoing radical surgery for gastrointestinal malignant tumor.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 52 (actual)
- First submitted
- 3 Dec 2022
- Start date
- 1 Oct 2023
- Primary completion date
- 30 Jul 2024
- Lead sponsor
- Zhuan Zhang
- Diseases
- Lung cancer
- NCT number
- NCT05693246
What you commit to
- Study type: Interventional
- Participants enrolled: 52
- From 1 Oct 2023 to the primary completion date, 30 Jul 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- known allergy to glycopyrrolate;
- severe hepatic or renal insufficiency;
- a history of mechanical ventilation within the past six months;
- severe respiratory disease or restricted thoracic mobility such as thoracic deformity.
Other
- refusal to participate;
- myasthenia gravis;
- angle-closure glaucoma;
- tachycardia detected on the preoperative electrocardiogram (ECG);
- contraindications to epidural anesthesia;
Who the study is looking for
- aged 65 yrs or elder;
- gender unlimited;
- American Society of Anesthesiologists (ASA) class I to III;
- an expected surgical duration of at least 2 hrs.
Age in the registry: 65 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| the Affiliated Hospital of Yangzhou University, Yangzhou University Coordinator of this site? Confirm its status | Yangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.