NCT05693649Active, not recruiting
Behavioral Economic Approaches for Population-Based Colorectal Cancer Screening
Source: ClinicalTrials.gov · Last updated 5 Oct 2026
Brief summary (registry, in English)
This is a 3-year pragmatic, randomized clinical trial among average-risk patients at diverse primary care practices who are overdue for colorectal (CRC) screening. This project aims to evaluate the effect of a centralized program that includes direct outreach to patients and visit-based, clinician directed nudges facilitated by the electronic health record (EHR) with follow-up text messaging on the uptake of CRC screening. The primary outcome is CRC screening completion at 3 years. Patient and clinician factors impacting the experience and effectiveness of the intervention will be explored through surveys and qualitative interviews.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 20000 (estimated)
- First submitted
- 12 Jan 2023
- Start date
- 7 Jun 2023
- Primary completion date
- 21 Dec 2026
- Lead sponsor
- Abramson Cancer Center at Penn Medicine
- Diseases
- Colorectal cancer
- NCT number
- NCT05693649
What you commit to
- Study type: Interventional
- Planned participants: 20000
- From 7 Jun 2023 to the primary completion date, 21 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently on hospice or receiving palliative care
Other illness
- Personal or significant family history of CRC, colonic polyps, hereditary nonpolyposis colorectal cancer syndrome, familial adenomatous polyposis syndrome, other gastrointestinal cancer, gastrointestinal bleeding, iron-deficiency anemia, or inflammatory bowel disease
- History of total colectomy, dementia or metastatic cancer
- History of paraplegia or quadriplegia
Other
- Uninsured or self-pay patients
- Currently scheduled for a colonoscopy or sigmoidoscopy
- Active order for multitarget stool DNA testing (MT-sDNA)
- Elevated chance of mortality within 3 years according to mortality risk algorithm
- Active order for Fecal Immunochemical Test (FIT) in the last 60 days
- Positive stool test (FIT or MT-sDNA) result in the last 5 years
Who the study is looking for
- Patients ages 50-72
- Followed by Primary Care with a participating Penn Medicine PCP listed and at least one visit in the last 2 years
- Not up to date on colorectal cancer screening per Health Maintenance (no colonoscopy in the last 10 years, stool testing in the last year, flexible sigmoidoscopy in the last 5 years, MT-sDNA in the last 3 years).
Age in the registry: 50 years to 72 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Penn Medicine Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
Related publications
- Sequential choice vs colonoscopy outreach for colorectal cancer screening: Design and rationale of a pragmatic randomized clinical trial.Contemp Clin Trials · 2026 · PMID 41412475
This page is information, not medical advice. Discuss any trial with your doctor.