NCT05698589Recruiting
COMpassion for Psychiatric Disorders And Self-Stigma
Compassion Focused Therapy (CFT) for the Reduction of the Internalized Stigma of Mental Disorders: a Multi-center, Prospective, Randomized, Controlled Study
Source: ClinicalTrials.gov · Last updated 19 Aug 2026
Brief summary (registry, in English)
People with mental disorders face frequent stigmatizing attitudes and behaviors from others . In response to this, they tend to isolate themselves, with the risk of impeding care and the process of recovery and integration into society . Stigmatization can also be assimilated by patients themselves - i.e. self-stigma. Self-stigma is involved in diminished coping skills that lead to social avoidance and difficulties in adhering to care . Reducing self-stigma and its emotional corollary, shame, is thus crucial to attenuate the disability associated with mental illness. Shame is inherent to self-stigma and leads to difficulties in adhering to care as well as greater severity of clinical presentations . Compassion Focused Therapy (CFT) is a third wave cognitive behavioral therapy that targets shame reduction and hostile self-to-self relationship and allows for symptom improvement while increasing self-compassion, a major resilience factor . Although shame is a prominent part of the concept of self-stigma, the efficacy of CFT has never been evaluated in individuals with high levels of self-stigma. In this study, the investigators will evaluate the efficacy and acceptability of a group based CFT program on decreasing self-stigma, compared to treatment as usual (TAU) and a psychoeducation program whose efficacy has been assessed in a previous trial.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 336 (estimated)
- First submitted
- 9 Dec 2022
- Start date
- 3 Apr 2023
- Primary completion date
- 1 Mar 2028
- Lead sponsor
- University Hospital, Strasbourg, France
- Diseases
- Schizophrenia, Bipolar disorder, Autism
- NCT number
- NCT05698589
What you commit to
- Study type: Interventional
- Planned participants: 336
- From 3 Apr 2023 to the primary completion date, 1 Mar 2028
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient in an exclusion period determined by a previous or ongoing study
- Patient participating in an interventional study involving psychotherapy or an experimental drug
Other illness
- Patient in acute episode of their disorder according to the CGI Severity score
Other
- Patient in a medical emergency or immediate life-threatening situation
- Patients with an intellectual disability (IQ\<70) estimated via the fNART (Mackinnon \& Mulligan, 2005)
- 12\. Legal issues: care under constraint or patient deprived of freedom because of a judicial measure 13. Patient who does not speak and read French sufficiently
Who the study is looking for
- Patient ≥18 years of age
- Patient informed of the results of the preliminary medical examination
- Patient affiliated to a social health insurance plan (beneficiary or beneficiary's family)
- Patient with one or several diagnoses of chronic psychiatric disorder (schizophrenia, schizoaffective disorder, bipolar disorder, recurrent major depression, borderline personality disorder) or a neurodevelopmental disorder (autism spectrum disorder) treated as an outpatient or in a day hospital
- CGI-Severity score\<6 assessed by the psychiatrist (Berk et al., 2008) ISMI score indicating moderate to high self-stigma (\>2.5; Lysaker et al., 2007)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Pôle de Psychiatrie Adulte, Hôpital Charles Perrens Coordinator of this site? Confirm its status | Bordeaux | France | Not yet recruiting |
| CH Le Vinatier Coordinator of this site? Confirm its status | Bron | France | Not yet recruiting |
| CHU de Clermont-Ferrand, Hôpital Gabriel Montpied, Service de Psychiatrie B Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Not yet recruiting |
| Pôle Hospitalo-Universitaire de Psychiatrie d'adultes et d'addictologie du Grand Nancy, Centre Psychothérapique de Nancy Coordinator of this site? Confirm its status | Laxou | France | Not yet recruiting |
| CHU de Montpellier, Psychiatrie d'adultes, Hôpital la Colombière Coordinator of this site? Confirm its status | Montpellier | France | Not yet recruiting |
| Etablissement Public de Santé Mentale (EPSM) de la Marne, Site Pierre-Briquet, Unité de réhabilitation psychosociale Coordinator of this site? Confirm its status | Reims | France | Not yet recruiting |
| Service de Psychiatrie, Hôpital Civil, Hôpitaux Universitaires de Strasbourg Coordinator of this site? Confirm its status | Strasbourg | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.