NCT05699460Completed
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
A Pre-Gene Therapy Study of Early Parkinson's or Multiple System Atrophy Progression by Longitudinal Clinical and Biomarker Assessments
Source: ClinicalTrials.gov · Last updated 27 Jul 2026
Brief summary (registry, in English)
The objective of this study is to describe disease progression in study participants diagnosed with early Parkinson's Disease or Multiple System Atrophy - Parkinsonian Type up to 18 months as delineated by clinical and biochemical parameters.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 73 (actual)
- First submitted
- 13 Oct 2022
- Start date
- 29 Sept 2022
- Primary completion date
- 4 Nov 2025
- Lead sponsor
- AskBio Inc
- Diseases
- Parkinson disease
- NCT number
- NCT05699460
What you commit to
- Study type: Observational
- Participants enrolled: 73
- From 29 Sept 2022 to the primary completion date, 4 Nov 2025
- 11 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior brain surgery (i.e. deep brain stimulation) or other brain imaging abnormalities
- Receiving an investigational drug
- NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Other illness
- Movement disorder due to known cerebrovascular disease, brain tumor, trauma, exposure to parkinsonian-linked toxicants or other neurological diseases
- Presence of dementia, psychosis, substance abuse or poorly controlled depression
- History of cancer or poorly controlled medical conditions
Who the study is looking for
- Diagnosis of Idiopathic PD
- Diagnosis of MSA-P
- One to six years from clinical diagnosis of PD
- Less than 4 years from clinical diagnosis of MSA with expected survival \>3 years
- Stable medication regimen
- Ability to walk with or without an assistive device
Age in the registry: 35 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (11)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Specjalistyczna Praktyka Lekarska, Prof. Grzegorz Opala Coordinator of this site? Confirm its status | Katowice | Poland | Unknown status |
| Zespol Poradni Specjalistycznych - Botaniczna 3 Poradnia Neurologiczna Szpital Uniwersytecki w Krakowie Coordinator of this site? Confirm its status | Krakow | Poland | Unknown status |
| Samodzielny Publiczny Szpital Kliniczny im. prof. Witolda Orłowskiego, Oddział Neurologii i Epileptologii Coordinator of this site? Confirm its status | Warsaw | Poland | Unknown status |
| Mazowiecki Szpital Bródnowski w Warszawie, Oddział Neurologii Coordinator of this site? Confirm its status | Warsaw | Poland | Unknown status |
| Parkinson's Disease and Movement Disorders Center of Boca Raton Coordinator of this site? Confirm its status | Boca Raton | United States | Unknown status |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Ohio Health Research Institute Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| QUEST Research Institute Coordinator of this site? Confirm its status | Farmington Hills | United States | Unknown status |
| University of California, Irvine Coordinator of this site? Confirm its status | Irvine | United States | Unknown status |
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| OHSU Parkinson Center & Movement Disorders Program Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.