NCT05699538Completed
Fatigability in Long COVID-19
Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection
Source: ClinicalTrials.gov · Last updated 18 May 2026
Brief summary (registry, in English)
The overall goal of this project is to advance the understanding of underlying mechanisms impacting performance fatigability and perceived fatigability in Veterans with post-COVID-19 fatigue and explore the safety and feasibility of a home-based "minimal-dose" resistance exercise program in this population. The central hypothesis is that declines in force capacity, skeletal muscle oxygen extraction, and affective responses to physical activity offer potential mechanisms through which fatigability is increased in Veterans with post-COVID-19 fatigue. Moreover, home-based resistance exercise delivered remotely may provide a safe and feasibility treatment option for targeting neuromuscular and neurobehavioral factors influencing fatigability severity in this population.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 21 (actual)
- First submitted
- 24 Jan 2023
- Start date
- 31 Jul 2023
- Primary completion date
- 4 Jul 2025
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT05699538
What you commit to
- Study type: Interventional
- Participants enrolled: 21
- From 31 Jul 2023 to the primary completion date, 4 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- antibody test or clinical diagnosis or with a confirmed diagnosis of COVID-19 of \<12-weeks
- diagnosis of psychiatric disorder(s)
- musculoskeletal disease, or other conditions that, in the opinion of the principal investigator, could make participation in the study unsafe
Age
- \<50 years of age without a confirmed diagnosis of COVID-19 by PCR test
Other
- non-ambulatory individuals
- Veterans who do not use the DC VAMC as their main site for care
- body mass index 40 kg/m2
- any medically uncontrolled cardiovascular
- any orthopedic or joint pain which would prevent the participant from safely engaging in the study protocol
- additionally, individuals with plans to relocate from the DC metro area within one year will not be eligible for the intervention portion of the study
Who the study is looking for
- ambulatory patients (with or without a gait aid)
- 50 years of age or older
- with a confirmed diagnosis of COVID-19 by polymerase chain reaction (PCR) test, antibody test or clinical diagnosis
- the symptom of fatigue reported greater than 12-weeks post-infection (reporting fatigue: yes/no)
- receiving care at the DC VAMC
- the ability to speak and read English, and orientation to person, place, and time
- the comparison group will include ambulatory patients (with or without a gait aid)
- 50 years of age or older
- with a confirmed diagnosis of COVID-19 by PCR test, antibody test or clinical diagnosis
- without the symptom of fatigue reported greater than 12-weeks post-infection
- receiving care at the DC VAMC
- the ability to speak and read English, and orientation to person, place, and time
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Washington DC VA Medical Center, Washington, DC Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.