NCT05703919RecruitingPhase 4
Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The primary objective is to determine whether a titrated oxygen strategy targeting SpO₂ 88-92% can reduce 30-day mortality compared to the current standard practice using 100% compressed oxygen as a nebulizer driver.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 1888 (estimated)
- First submitted
- 10 Jan 2023
- Start date
- 2 Jun 2025
- Primary completion date
- 29 Feb 2028
- Lead sponsor
- Central Denmark Region
- Diseases
- COPD
- NCT number
- NCT05703919
- EU CT number
- 2022-502003-30-00
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 1888
- From 2 Jun 2025 to the primary completion date, 29 Feb 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- More than 2 doses (5 mg salbutamol) inhalation drug, acute treatment by EMS (emergency medical service) personnel, before allocated treatment is initiated
Other illness
- Bronchospasm due to asthma, allergic reaction or non-COPD conditions
- Allergy to inhaled bronchodilators (Salbutamol)
- Suspicion of acute coronary syndrome
Other
- Known or suspected pregnancy
- Prehospital Non-invasive, invasive or assisted bag mask ventilation
- Inter-hospital transfer
Who the study is looking for
- Patients over the age of 40
- EMT or Paramedic suspected AECOPD
- Confirmed suspicion of COPD
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Præhospitalet Coordinator of this site? Confirm its status | Aarhus N | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.