NCT05704101Completed
NHFT Effects on Symptatheic Drive of Asthma Patients
Influence of Nasal High-flow Therapy (NHFT) on Ventilation and Sympathetic Drive in Patients With Asthma
Source: ClinicalTrials.gov · Last updated 28 Jan 2026
Brief summary (registry, in English)
The project will be pursued in our respiratory, autonomic nervous system physiology laboratory (Respiratory, autonomic nervous system physiology laboratory, Department of Pneumology and Intensive Care Medicine, RWTH Aachen University Hospital). Overactivity of the sympathetic nerve activity (SNA) axis with "centrally" increased heart rate and peripheral vasoconstriction is a known phenomenon in patients with systolic heart failure (HF) and has recently been described in patients with primary lung diseases as in chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH). Comprehensive studies investigating sympathetic drive in Asthma as one of the major pulmonary diseases are still lacking. Furthermore, the intention of this study is to determine the impact of Nasal High Flow Therapy (NHFT) on SNA and assess respiratory muscle function using state-of-the-art techniques.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 30 (actual)
- First submitted
- 6 Jan 2023
- Start date
- 1 Jul 2023
- Primary completion date
- 1 Jun 2025
- Lead sponsor
- RWTH Aachen University
- Diseases
- Asthma
- NCT number
- NCT05704101
What you commit to
- Study type: Observational
- Participants enrolled: 30
- From 1 Jul 2023 to the primary completion date, 1 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- In-patient stay in the hospital within the last 4 weeks prior to the study examination date
Other illness
- Active pacing of the heart by a cardiac pacemaker (i.e. no intrinsic heart rate)
- Clinically pre-established cardiovascular disease or other pulmonary diseases (e.g. arterial hypertension, systolic heart failure, COPD)
Other
- Atrial fibrillation
- Severe polyneuropathy
Who the study is looking for
- Clinically diagnosed Asthma
- Age ≥ 18
- Ability and willingness to give informed consent to participate in the study
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital RWTH Aachen-Department of Pneumology and Intensive Care Coordinator of this site? Confirm its status | Aachen | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.