NCT05704205Active, not recruiting
The UPDATE Trial (Uvb Phototherapy in Dermatology for ATopic Eczema)
The UPDATE Trial (Uvb Phototherapy in Dermatology for ATopic Eczema): A Multicenter Randomized Controlled Trial of Narrowband UVB Versus Optimized Topical Therapy in Patients With Atopic Eczema
Source: ClinicalTrials.gov · Last updated 23 Jan 2026
Brief summary (registry, in English)
The goal of this randomized controlled trial is to study the (cost)effectiveness of NB-UVB phototherapy in patients with atopic eczema/atopic dermatitis. Half of the participants will undergo a course of NB-UVB phototherapy of 8-16 weeks and apply optimal topical therapy (OTT) for a minimum of 3 months. Researchers will compare the outcomes of this group with the other half of participants that apply OTT only.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 316 (estimated)
- First submitted
- 8 Dec 2022
- Start date
- 22 Feb 2023
- Primary completion date
- 16 Jan 2026
- Lead sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Diseases
- Atopic dermatitis (eczema)
- NCT number
- NCT05704205
What you commit to
- Study type: Interventional
- Planned participants: 316
- From 22 Feb 2023 to the primary completion date, 16 Jan 2026
- 16 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient is already on systemic AE therapy;
- NB-UVB or any systemic therapy in the past 9 months.
Other illness
- Contra-indication for NB-UVB;
- Genetic defects associated with photosensitivity or skin cancer;
- Heavily photo-damaged skin;
- History of multiple (\>1) skin malignancies;
- Use of systemic immunosuppressants/immunomodulators;
- Use of medication associated with photosensitivity;
Other
- Patient is already on OTT in the past 2 months;
Who the study is looking for
- Adult (≥18 years of age) patient meeting the UK working party criteria for atopic eczema;
- AE insufficiently controlled by standard topical care and therefore eligible for NB-UVB or OTT;
- Investigator Global Assessment (IGA, 0-4) of ≥ 2 (moderate disease);
- Eczema Area and Severity Index (EASI) of ≥ 7 (moderate disease);
- Understood and voluntarily signed and dated an informed consent form prior to any study-related procedure or has a legal representative who has, and is willing to comply with the study's requirements.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (16)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centrum Oosterwal Coordinator of this site? Confirm its status | Alkmaar | Netherlands | Unknown status |
| Flevoziekenhuis Coordinator of this site? Confirm its status | Almere Stad | Netherlands | Unknown status |
| Meander Medisch Centrum Coordinator of this site? Confirm its status | Amersfoort | Netherlands | Unknown status |
| Huid Medisch Centrum Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Unknown status |
| OLVG Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Unknown status |
| Amsterdam Universitair Medische Centra Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Unknown status |
| Reinier de Graaf Gasthuis Coordinator of this site? Confirm its status | Delft | Netherlands | Unknown status |
| Bergman Clinics Coordinator of this site? Confirm its status | Haarlem | Netherlands | Unknown status |
| Spaarne Gasthuis Coordinator of this site? Confirm its status | Hoofddorp | Netherlands | Unknown status |
| Medisch Centrum Leeuwarden Coordinator of this site? Confirm its status | Leeuwarden | Netherlands | Unknown status |
| Leids Universitair Medisch Centrum Coordinator of this site? Confirm its status | Leiden | Netherlands | Unknown status |
| Alrijne Ziekenhuis Coordinator of this site? Confirm its status | Leiderdorp | Netherlands | Unknown status |
| Dijklander Ziekenhuis Coordinator of this site? Confirm its status | Purmerend | Netherlands | Unknown status |
| Erasmus Medisch Centrum Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Unknown status |
| Jeroen Bosch Ziekenhuis Coordinator of this site? Confirm its status | 's-Hertogenbosch | Netherlands | Unknown status |
| Isala Klinieken Coordinator of this site? Confirm its status | Zwolle | Netherlands | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.