NCT05704309Enrolling by invitation
The Diabetes Prevention Program Outcomes Study AD/ADRD Project
Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project
Source: ClinicalTrials.gov · Last updated 26 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for cognitive impairment and represent a large fraction of the United States (US) population? This U19 proposal addresses the National Alzheimer's Project Act goal to "prevent, halt, or reverse AD" in the high-risk group of persons with pre-diabetes and type 2 diabetes, who represent over half of the population aged 60 years and older in the US.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 1976 (estimated)
- First submitted
- 11 Jan 2023
- Start date
- 7 Nov 2022
- Primary completion date
- 31 Jan 2027
- Lead sponsor
- Marinella Temprosa
- Diseases
- Alzheimer disease, Type 2 diabetes
- NCT number
- NCT05704309
What you commit to
- Study type: Observational
- Planned participants: 1976
- From 7 Nov 2022 to the primary completion date, 31 Jan 2027
- 27 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- \-
Who the study is looking for
- All surviving participants originally randomized in the Diabetes Prevention Program
- For Brain Imaging subcohort, only participants aged 55 years and older and those without contraindication to MRI will be included. Contraindications to MRI include the inability to lie flat, claustrophobia, and the presence of indwelling metallic objects, medical or non-medical, that are not 3T MRI compatible.
Sex: All · Accepts healthy volunteers
Sites (27)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of New Mexico Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| University of California Los Angeles Coordinator of this site? Confirm its status | Alhambra | United States | Unknown status |
| University of Colorado Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Pennington Biomedical Center Coordinator of this site? Confirm its status | Baton Rouge | United States | Unknown status |
| Joslin Diabetes Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Northwestern University Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of Chicago Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of Hawaii Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Indiana University Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Johns Hopkins University Coordinator of this site? Confirm its status | Lutherville | United States | Unknown status |
| University of Tennessee Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| University of Miami Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Columbia University Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Columbia University Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Thomas Jefferson University Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| SW American Indian Center - Phoenix Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| University of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Biostatistics Center, George Washington University Coordinator of this site? Confirm its status | Rockville | United States | Unknown status |
| University of Texas Health Science Center San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| University of California San Diego Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| University of Washington, VA Puget Sound Health Care System Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| SW American Indian Center - Shiprock Coordinator of this site? Confirm its status | Shiprock | United States | Unknown status |
| Washington University Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Albert Einstein College of Medicine Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
| Medstar Health Research Institute Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| SW American Indian Center - Zuni Coordinator of this site? Confirm its status | Zuni | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.