Fact CheckerSign in

NCT05704309Enrolling by invitation

The Diabetes Prevention Program Outcomes Study AD/ADRD Project

Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project

Source: ClinicalTrials.gov · Last updated 26 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open

Brief summary (registry, in English)

The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for cognitive impairment and represent a large fraction of the United States (US) population? This U19 proposal addresses the National Alzheimer's Project Act goal to "prevent, halt, or reverse AD" in the high-risk group of persons with pre-diabetes and type 2 diabetes, who represent over half of the population aged 60 years and older in the US.

Status (registry)
Enrolling by invitation
Study type
Observational
Enrollment
1976 (estimated)
First submitted
11 Jan 2023
Start date
7 Nov 2022
Primary completion date
31 Jan 2027
Lead sponsor
Marinella Temprosa
NCT number
NCT05704309

What you commit to

  • Study type: Observational
  • Planned participants: 1976
  • From 7 Nov 2022 to the primary completion date, 31 Jan 2027
  • 27 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • \-

Who the study is looking for

  • All surviving participants originally randomized in the Diabetes Prevention Program
  • For Brain Imaging subcohort, only participants aged 55 years and older and those without contraindication to MRI will be included. Contraindications to MRI include the inability to lie flat, claustrophobia, and the presence of indwelling metallic objects, medical or non-medical, that are not 3T MRI compatible.

Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (27)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
University of New Mexico
Coordinator of this site? Confirm its status
AlbuquerqueUnited StatesUnknown status
University of California Los Angeles
Coordinator of this site? Confirm its status
AlhambraUnited StatesUnknown status
University of Colorado
Coordinator of this site? Confirm its status
AuroraUnited StatesUnknown status
Pennington Biomedical Center
Coordinator of this site? Confirm its status
Baton RougeUnited StatesUnknown status
Joslin Diabetes Center
Coordinator of this site? Confirm its status
BostonUnited StatesUnknown status
Massachusetts General Hospital
Coordinator of this site? Confirm its status
BostonUnited StatesUnknown status
Northwestern University
Coordinator of this site? Confirm its status
ChicagoUnited StatesUnknown status
University of Chicago
Coordinator of this site? Confirm its status
ChicagoUnited StatesUnknown status
University of Hawaii
Coordinator of this site? Confirm its status
HonoluluUnited StatesUnknown status
Indiana University
Coordinator of this site? Confirm its status
IndianapolisUnited StatesUnknown status
Johns Hopkins University
Coordinator of this site? Confirm its status
LuthervilleUnited StatesUnknown status
University of Tennessee
Coordinator of this site? Confirm its status
MemphisUnited StatesUnknown status
University of Miami
Coordinator of this site? Confirm its status
MiamiUnited StatesUnknown status
Columbia University Medical Center
Coordinator of this site? Confirm its status
New YorkUnited StatesUnknown status
Columbia University
Coordinator of this site? Confirm its status
New YorkUnited StatesUnknown status
Thomas Jefferson University
Coordinator of this site? Confirm its status
PhiladelphiaUnited StatesUnknown status
SW American Indian Center - Phoenix
Coordinator of this site? Confirm its status
PhoenixUnited StatesUnknown status
University of Pittsburgh
Coordinator of this site? Confirm its status
PittsburghUnited StatesUnknown status
Biostatistics Center, George Washington University
Coordinator of this site? Confirm its status
RockvilleUnited StatesUnknown status
University of Texas Health Science Center San Antonio
Coordinator of this site? Confirm its status
San AntonioUnited StatesUnknown status
University of California San Diego
Coordinator of this site? Confirm its status
San DiegoUnited StatesUnknown status
University of Washington, VA Puget Sound Health Care System
Coordinator of this site? Confirm its status
SeattleUnited StatesUnknown status
SW American Indian Center - Shiprock
Coordinator of this site? Confirm its status
ShiprockUnited StatesUnknown status
Washington University
Coordinator of this site? Confirm its status
St LouisUnited StatesUnknown status
Albert Einstein College of Medicine
Coordinator of this site? Confirm its status
The BronxUnited StatesUnknown status
Medstar Health Research Institute
Coordinator of this site? Confirm its status
Washington D.C.United StatesUnknown status
SW American Indian Center - Zuni
Coordinator of this site? Confirm its status
ZuniUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.