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NCT05708443Recruiting

Effect of Combined Endurance Training on ADL and Walking in COPD Patients

Effect of Combined Upper and Lower Extremity Endurance Training Versus Lower Extremity Training Alone on ADL and Walking in COPD Patients

Source: ClinicalTrials.gov · Last updated 24 Jun 2026

Brief summary (registry, in English)

Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease with related exercise intolerance and marked disability due to symptoms such as dyspnea and fatigue. Effort intolerance and exercise-induced symptoms cause marked impairment in completing activities of daily living (ADL). Pulmonary rehabilitation (PR), which has exercise as a major component, is considered a key treatment in the management of COPD since PR is effective in improving exercise tolerance, exercise-induced dyspnea and fatigue, and health-related quality of life. Rehabilitation is also effective in improving the time required to perform ADLs, reducing symptoms and disability. Studies show that rehabilitation protocols with upper limb exercises added to lower limb training are able to give additional benefits in terms of effort tolerance (endurance time at the arm ergometer and oxygen consumption) and reduction of dyspnea at iso-load. The primary aim of this study is to evaluate whether the combined "arm and leg" training modality, compared to a gold standard protocol -involving only the lower limbs training- is more effective in improving ADL performance in terms of reduction of exercise time for a specific test (GLITTRE test).

Status (registry)
Recruiting
Study type
Interventional
Enrollment
36 (estimated)
First submitted
12 Jan 2023
Start date
10 Jan 2023
Primary completion date
28 Feb 2027
Lead sponsor
Istituti Clinici Scientifici Maugeri SpA
Diseases
COPD
NCT number
NCT05708443

What you commit to

  • Study type: Interventional
  • Planned participants: 36
  • From 10 Jan 2023 to the primary completion date, 28 Feb 2027
  • 3 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • recent exacerbation (within 15 days) requiring a change in therapy

Other illness

  • chronic respiratory insufficiency on long-term oxygen therapy (LTOT)
  • cognitive impairment
  • presence of lung disease other than COPD

Other

  • severe orthopedic, neurological or cardiological comorbidities
  • terminality

Who the study is looking for

  • GOLD class 2-3 COPD
  • Forced Expiratory Volume in the first second (FEV1) between 30% and 70% of the predicted value
  • ability to walk and climb stairs without assistance
  • stable clinical condition (pH \> 7.35)

Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (3)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
ICS Maugeri IRCCS, Respiratory Rehabilitation of the Institute of Lumezzane
Coordinator of this site? Confirm its status
LumezzaneItalyRecruiting
ICS Maugeri IRCCS, respiratory rehabilitation of the Institute of Montescano
Coordinator of this site? Confirm its status
MontescanoItalyNot yet recruiting
ICS Maugeri IRCCS, Respiratory rehabilitation of the Institute of Tradate
Coordinator of this site? Confirm its status
TradateItalyCompleted

This page is information, not medical advice. Discuss any trial with your doctor.