NCT05708599Active, not recruiting
A Study to Compare Tissue and Liquid Biopsies in People With Different Types of Cancer
Longitudinal Liquid Biopsy Study Without an Investigational Medicinal Product in Patients With Non-Small Cell Lung Cancer (NSCLC) Including Squamous Cell Carcinoma, Adenocarcinoma and Large Cell Carcinoma, Colorectal Carcinoma (CRC) and Pancreatic Ductal Adenocarcinoma (PDAC) to Evaluate Novel Blood-based Biomarkers for Use in Early Clinical Development
Source: ClinicalTrials.gov · Last updated 21 Jan 2026
Brief summary (registry, in English)
In study, liquid biopsy samples will be obtained from non-small cell lung cancer (NSCLC) including Squamous cell carcinoma, Adenocarcinoma and large cell carcinoma, colorectal carcinoma (CRC) and pancreatic ductal adenocarcinoma (PDAC) patients who undergo treatment according to established standards of care (SoC) at the University Hospital Schleswig-Holstein (UKSH). This study will observe the overall Variant Allele Frequency (VAF) of circulating tumour Desoxyribonucleic acid (ctDNA) levels over the patient therapeutic treatment course and will correlate these findings with tumour response as well as Kirsten rat sarcoma viral oncogene homolog (KRAS)mutation status.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 102 (actual)
- First submitted
- 16 Jan 2023
- Start date
- 1 Mar 2023
- Primary completion date
- 8 Feb 2027
- Lead sponsor
- Boehringer Ingelheim
- Diseases
- Lung cancer, Pancreatic cancer, Colorectal cancer
- NCT number
- NCT05708599
What you commit to
- Study type: Interventional
- Participants enrolled: 102
- From 1 Mar 2023 to the primary completion date, 8 Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients not expected to comply with the protocol requirements or not expected to complete the study as scheduled (e.g. chronic alcohol or drug abuse or any other condition that, in the investigator's opinion, makes the patient an unreliable study participant).
Other
- Women who are pregnant or who plan to become pregnant during the study.
- Participation at a clinical trial involving an investigational medicine where the treatment details cannot be disclosed.
Who the study is looking for
- ≥18 years old
- Male or female patients with pancreatic ductal adenocarcinoma, colorectal carcinoma or adenocarcinoma of the lung as specified above leading to new treatment line.
- Signed and dated written informed consent in accordance with International Council on Harmonisation-Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the study.
- Willingness to undergo pre- and on-treatment liquid biopsies for biomarker assessment. Patients can be enrolled without tissue tumour biopsy upon agreement between the Investigator and the Sponsor.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universitätsklinikum Schleswig-Holstein, Campus Kiel Coordinator of this site? Confirm its status | Kiel | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.