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NCT05715125TerminatedPhase 2

VTX958 Versus Placebo for the Treatment of Active Psoriatic Arthritis (Tranquility-PsA)

A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VTX958 in Patients With Active Psoriatic Arthritis

Source: ClinicalTrials.gov · Last updated 27 Dec 2024

Reason given: sponsor decision

Brief summary (registry, in English)

The objective of this study is to evaluate if VTX958 is safe and effective in adult participants with active Psoriatic Arthritis. Approximately 195 eligible participants will take VTX958 Dose A, VTX958 Dose B, or matching placebo (no active drug) for 16 weeks and then move on to a 36 week Long Term Extension (LTE). The study will include 16 weeks of treatment, 36 weeks of LTE, and a 30-day follow-up period.

Status (registry)
Terminated
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
205 (actual)
First submitted
19 Jan 2023
Start date
31 Jan 2023
Primary completion date
2 Jan 2024
Lead sponsor
Ventyx Biosciences, Inc
NCT number
NCT05715125

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Has inflammatory bowel disease or active uveitis
  • Has a history of chronic or recurrent infectious disease
  • Has hepatitis B or hepatitis C infection, human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS), or active tuberculosis (TB) at screening

Other

  • Has non-plaque psoriasis at Screening or Day 1
  • Has a known immune deficiency or is immunocompromised

Who the study is looking for

  • Diagnosed with Psoriatic Arthritis for 6 months or more prior to Screening
  • Documented history or active signs of at least 1 confirmed lesion of plaque psoriasis and/or nail changes attributed to psoriasis
  • Active PsA as defined by 3 or more swollen joints and 3 or more tender joints at Screening and Day 1
  • Women must not be of childbearing potential or must agree to use a highly effective contraception during the study and for 30 days after the last dose of the study product
  • Men with a partner who is of childbearing potential must agree to use condoms during the study and for 90 days after the last dose of study product

Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (46)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
-HaskovoBulgariaUnknown status
-PlovdivBulgariaUnknown status
-PlovdivBulgariaUnknown status
-HlučínCzechiaUnknown status
-OstravaCzechiaUnknown status
-PardubiceCzechiaUnknown status
-PragueCzechiaUnknown status
-ZlínCzechiaUnknown status
-BerlinGermanyUnknown status
-HamburgGermanyUnknown status
-A CoruñaSpainUnknown status
-LleidaSpainUnknown status
-SevilleSpainUnknown status
-BudapestHungaryUnknown status
-HódmezővásárhelyHungaryUnknown status
-KistarcsaHungaryUnknown status
-GdyniaPolandUnknown status
-KatowicePolandUnknown status
-KrakowPolandUnknown status
-LodzPolandUnknown status
-LodzPolandUnknown status
-LodzPolandUnknown status
-LublinPolandUnknown status
-NadarzynPolandUnknown status
-OlsztynPolandUnknown status
-PoznanPolandUnknown status
-TorunPolandUnknown status
-WarsawPolandUnknown status
-WarsawPolandUnknown status
-WroclawPolandUnknown status
-WroclawPolandUnknown status
-BaytownUnited StatesUnknown status
-BeckleyUnited StatesUnknown status
-ClearwaterUnited StatesUnknown status
-DuncansvilleUnited StatesUnknown status
-EaganUnited StatesUnknown status
-LexingtonUnited StatesUnknown status
-LubbockUnited StatesUnknown status
-MesquiteUnited StatesUnknown status
-Miami LakesUnited StatesUnknown status
-Middleburg HeightsUnited StatesUnknown status
-Newport BeachUnited StatesUnknown status
-OkemosUnited StatesUnknown status
-PhoenixUnited StatesUnknown status
-Saint Clair ShoresUnited StatesUnknown status
-South CharlestonUnited StatesUnknown status

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This page is information, not medical advice. Discuss any trial with your doctor.