NCT05723107RecruitingPhase 1
EUS RFA for Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)
Phase I Pilot Study of Endoscopic Ultrasound Guided RFA in Advanced Pancreatic Cancer
Source: ClinicalTrials.gov · Last updated 28 Nov 2025
Brief summary (registry, in English)
This is a single arm study in the treatment of pancreatic ductal adenocarcinoma (PDAC). The investigators propose to test the tolerability of chemotherapy plus endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) using the RF Electrode in patients receiving palliative second or third line therapy for unresectable non-metastatic pancreatic cancer.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- First submitted
- 1 Feb 2023
- Start date
- 31 Mar 2023
- Primary completion date
- 30 Nov 2027
- Lead sponsor
- NYU Langone Health
- Diseases
- Pancreatic cancer
- NCT number
- NCT05723107
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 15
- From 31 Mar 2023 to the primary completion date, 30 Nov 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Patients that show evidence of distant metastasis
- Endoscopically non-accessible mass
- Pregnant patients
- Inability to provide informed consent
- Lesions \<1cm, or \>4cm in greatest diameter
Who the study is looking for
- Diagnosed and histologically confirmed PDAC by biopsy
- Axial CT scan or MRI consistent with PDAC with at least 1 cm in greatest diameter
- ECOG performance status 0-2
- Patients with locally advanced PDAC, who have not responded or progressed on first line chemotherapy, are deemed not resectable based on multidisciplinary review, and show no evidence of distant metastasis
- Lesions between 1 - 4cm in size
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tisch Hospital Coordinator of this site? Confirm its status | New York | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.