NCT05723679Recruiting
Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
Targeting Breathing Limitations to Improve Functional Outcomes in Heart Failure With Preserved Ejection Fraction (HFpEF)
Source: ClinicalTrials.gov · Last updated 7 May 2026
Brief summary (registry, in English)
The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 78 (estimated)
- First submitted
- 27 Jan 2023
- Start date
- 1 Jul 2023
- Primary completion date
- 30 Jun 2028
- Lead sponsor
- University of Texas Southwestern Medical Center
- Diseases
- Heart failure, Obesity
- NCT number
- NCT05723679
What you commit to
- Study type: Interventional
- Planned participants: 78
- From 1 Jul 2023 to the primary completion date, 30 Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- phosphodiesterase type 5 (PDE5) inhibitor use
Other illness
- Atrial fibrillation with poorly controlled heart rate
- severe valvular disease
- severe Chronic obstructive pulmonary disease (COPD)
- Chronic kidney disease (CKD) 4 or higher
Age
- age \< 55 years
Other
- BMI \> 50 kg/m2
- any restriction of ambulation and mobility.
Who the study is looking for
- signs and symptoms of heart failure
- an ejection fraction \> 0.50;
- objective evidence of diastolic dysfunction. elevated biomarkers (NT-proBNP \>300 ng/dl) or HF hospitalization
- healthy volunteers
Age in the registry: 55 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UT Southwestern Medical Center Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.