NCT05724264Recruiting
SingapOre Lung Cancer Screening Through Integrating CT With Other biomarkErs (SOLSTICE)
Source: ClinicalTrials.gov · Last updated 15 May 2026
Brief summary (registry, in English)
This is a single arm screening study. All eligible participants will be subjected to low dose CT (LDCT) screening and biomarker testing. The primary aim of the study is to determine the feasibility of conducting LDCT screening in at-risk populations for lung cancer in Singapore: * For the smoker population, LDCT screening for lung cancer will be implemented in accordance to Academy of Medicine, Singapore screening test guidelines with the aim of investigating the feasibility of instituting lung cancer screening clinical service in Singapore. * For the non-smoker population, LDCT screening for lung cancer will be introduced to systematically collect baseline data to better understand and provide evidence for lung adenocarcinoma in never-smoker phenotype that is unique to East Asia/Singapore. This will help address unmet needs in local population research as reported by Academy of Medicine, Singapore, to validate risk factors and inform future screening guidelines for the at-risk population. Screening results will be reported based on Lung CT Screening Reporting \& Data System (Lung-RADS).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1000 (estimated)
- First submitted
- 19 Jan 2023
- Start date
- 21 Jul 2022
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- National Cancer Centre, Singapore
- Diseases
- Lung cancer
- NCT number
- NCT05724264
What you commit to
- Study type: Interventional
- Planned participants: 1000
- From 21 Jul 2022 to the primary completion date, 31 Dec 2029
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous diagnosis of cancer
Other illness
- Bleeding diathesis that will preclude blood sampling
Other
- Uncontrolled medical comorbidity on enrolment
- Fear of blood draw or needles
- Pregnancy
Who the study is looking for
- Smoker:
- Participant is willing and able to give informed consent for participation in the study
- Male or female, aged 50-80 years of age
- No prior history of cancer, or cancer free in the last 5 years and not currently on cancer treatment
- ECOG 0/1
- Current or former smokers with at least 30 pack years of smoking history
- Willing to comply with study follow-up schedule and tests
- Willing to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc.
- A Singapore citizen/Permanent Resident of Singapore
- Non-Smoker:
- Participant is willing and able to give informed consent for participation in the study
- Male, or female, aged 50-80 years of age
- No prior history of cancer, or cancer free in the last 5 years and not currently on cancer treatment
- ECOG 0/1
- Never smoker, or has smoked less than 10 pack-years and has quit smoking for at least 15 years
- Family history of lung cancer up to 2nd degree relatives
- Willing to comply with study follow-up schedule and tests
- Willing to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc.
- A Singapore citizen/Permanent Resident of Singapore
Age in the registry: 50 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sengkang General Hospital, Singapore Coordinator of this site? Confirm its status | Singapore | Singapore | Recruiting |
| National Heart Centre Singapore Coordinator of this site? Confirm its status | Singapore | Singapore | Active, not recruiting |
| National Cancer Centre Singapore Coordinator of this site? Confirm its status | Singapore | Singapore | Recruiting |
| Changi General Hospital, Singapore Coordinator of this site? Confirm its status | Singapore | Singapore | Recruiting |
| Tan Tock Seng Hospital, Singapore Coordinator of this site? Confirm its status | Singapore | Singapore | Recruiting |
| Singapore General Hospital Coordinator of this site? Confirm its status | Singapore | Singapore | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.