NCT05726019CompletedPhase 2
Colchicine in Patients Undergoing Coronary Artery Bypass Grafting After Acute Coronary Syndrome
Colchicine in Patients Undergoing Coronary Artery Bypass Grafting After Acute Coronary Syndrome: an Open-label Randomized Trial
Source: ClinicalTrials.gov · Last updated 3 Mar 2026
Brief summary (registry, in English)
The present study seeks to evaluate the effectiveness of the use of perioperative colchicine with regard to operative complications, in patients with acute coronary syndrome and indication for cardiac post-surgical revascularization. Patients will be selected and randomized while still in the emergency room and medication (colchicine 0.5mg every 12 hours or placebo) will be started within 24 hours of randomization, being maintained for 30 days after surgery.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 100 (actual)
- First submitted
- 2 Feb 2023
- Start date
- 5 Feb 2022
- Primary completion date
- 21 Dec 2025
- Lead sponsor
- University of Sao Paulo General Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT05726019
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 100
- From 5 Feb 2022 to the primary completion date, 21 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of long-term corticosteroid therapy
- Drug addiction or alcoholism;
Other illness
- Inflammatory bowel disease or chronic diarrhea;
- Severe liver disease;
- History of clinically significant sensitivity to colchicine.
Lab values
- Renal dysfunction, with creatinine greater than 2 times the upper limit of normality;
Other
- Inability to sign the informed consent form;
- Current use of colchicine;
- Clinically significant non-transient haematological abnormalities;
Who the study is looking for
- Patients with acute coronary syndrome, with indication for myocardial revascularization surgery
- Patients of both genders, aged over 18 years.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Heart Institute University of São Paulo Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.