NCT05726136RecruitingPhase 4
Fluid Challenge and Plasma Volume, During Surgery
Comparison of Albumin and Ringer's Solution for Optimization of the Plasma Volume and Hemodynamics During Laparoscopic Surgery.
Source: ClinicalTrials.gov · Last updated 30 Apr 2026
Brief summary (registry, in English)
A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique. The purpose with the study is to examine the plasma expanding effect of three different fluid challenge strategies (acetated Ringers 4 ml/kg body weight, albumin 5% 4 ml/kg body weight or albumin 20% 1 ml/kg body weight), using hemoglobin as a dilution indicator.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 15 Jan 2023
- Start date
- 23 Oct 2023
- Primary completion date
- 31 Oct 2026
- Lead sponsor
- Joachim Zdolsek
- Diseases
- Colorectal cancer
- NCT number
- NCT05726136
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 60
- From 23 Oct 2023 to the primary completion date, 31 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with known cardiac failure
- kidney failure
Lab values
- known allergy to albumin
Age
- \<18 or \>85 years
Other
- extracellular hyperhydration or hypervolemia
- pregnancy or planned pregnancy
Who the study is looking for
- Written consent to participate in the study
- For women: relevant contraceptive, menopausal or a negative pregnancy test.
- ASA category I to III
- Laparoscopic abdominal surgery, with a duration of at least 90 minutes.
- 18 to 85 years
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vrinnevi Hospital Coordinator of this site? Confirm its status | Norrköping | Sweden | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.