NCT05726240RecruitingPhase 2
Multicentre Randomized trial of Ghrelin in anterior circulation ischemic stroke treated with endovascular thrombectomy. A randomized phase 2 trial.
Source: EU CTIS (euclinicaltrials.eu) · Last updated 11 Dec 2025
Brief summary (registry, in English)
The primary objective of this study is to assess the effect of ghrelin on the severity of the neurological deficit at seven days after symptom onset in patients with acute ischemic stroke caused by large vessel occlusion of the anterior circulation and treated with EVT.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 17 Sept 2024
- Start date
- 11 Nov 2024
- Lead sponsor
- Rijnstate Ziekenhuis Stichting
- Diseases
- Stroke
- NCT number
- NCT05726240
- EU CT number
- 2024-515705-26-00
- EudraCT number
- 2022-001632-28
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 80
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Other illness
- pre-stroke disability defined as mRS ≥ 2
Other
- life expectancy shorter than one year
- child-bearing potential
Who the study is looking for
- a clinical diagnosis of acute ischemic stroke, caused by intracranial large vessel occlusion of the anterior circulation (distal intracranial carotid artery or middle (M1/proximal M2) cerebral artery) confirmed by neuro-imaging (CTA or MRA)
- treatment with EVT, defined as groin puncture in the angio suite
- CT or MRI ruling out intracranial hemorrhage
- a pre-EVT score of at least 10 on the NIHSS
- age of 18 years or older
- written informed consent (deferred)
- possibility to start trial treatment within 6 hours of stroke onset
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rijnstate Ziekenhuis Stichting Coordinator of this site? Confirm its status | Arnhem | Netherlands | Recruiting |
| Medisch Spectrum Twente Coordinator of this site? Confirm its status | Enschede | Netherlands | Recruiting |
| Universitair Medisch Centrum Utrecht Coordinator of this site? Confirm its status | Utrecht | Netherlands | Recruiting |
| Isala Klinieken Stichting Coordinator of this site? Confirm its status | Zwolle | Netherlands | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.