NCT05734690CompletedPhase 4
COPILOT-HF: Cooperative Program for ImpLementation of Optimal Therapy in Heart Failure
Source: ClinicalTrials.gov · Last updated 6 Feb 2026
Brief summary (registry, in English)
This is a randomized, open-label, initiative within the Mass General Brigham healthcare system testing two remote care strategies for optimizing the prescription of guideline-directed medical therapies in patients with heart failure, regardless of left ventricular ejection fraction (LVEF).
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 503 (actual)
- First submitted
- 9 Feb 2023
- Start date
- 5 May 2023
- Primary completion date
- 19 May 2025
- Lead sponsor
- Brigham and Women's Hospital
- Diseases
- Heart failure
- NCT number
- NCT05734690
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 503
- From 5 May 2023 to the primary completion date, 19 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Active chemotherapy
- Receiving end-of-life care or hospice
Other illness
- Current severe aortic stenosis or severe aortic insufficiency
- Known amyloid heart disease
- Group 1 pulmonary arterial hypertension on disease-specific therapies (e.g., Ambrisentan, Bosentan, Epoprostenol, Treprostinil, Iloprost)
- History of transplant, currently listed above status 4 or being evaluated for transplant
Lab values
- LVEF\<50% currently prescribed or intolerant to both ARNi and SGLT2i
- LVEF\>50% currently prescribed or intolerant to SGLT2i
- eGFR\<30 mL/min/1.73m2
Other
- Systolic blood pressure (SBP) \<90 mmHg at last measure
- Outpatient intravenous inotrope use
- Current use of a Ventricular Assist Device
- Physician's discretion as inappropriate for remote management program
Who the study is looking for
- Documented diagnosis of heart failure (e.g., ICD-9 codes 428 ICD-10 codes I50 or Problem list in the electronic health record)
- Most recent EF assessed within the past 24 months
- Seen Mass General Brigham provider within the last 24 months
- English or Spanish speaking
Age in the registry: 18 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
Related publications
- Rationale and Design of the Cooperative Program for ImpLementation of Optimal Therapy in Heart Failure.Clin Cardiol · 2026 · PMID 41652651
This page is information, not medical advice. Discuss any trial with your doctor.