NCT05736653Completed
PCMS Task After Moderate-to-severe Stroke
Strengthening Task Specific Activation of Paretic Hand Muscles After moderate-to- Severe Chronic Stroke
Source: ClinicalTrials.gov · Last updated 27 May 2026
Brief summary (registry, in English)
Researchers at the University of Pittsburgh are conducting a research study to see how combining brain, nerve, and hand stimulation affect hand movement after stroke. The primary purpose of this study is to examine changes in the connection between the brain and the weak hand muscles after the combined brain, nerve, and hand stimulation. The primary hypothesis is that the combined brain, nerve, and hand stimulation will increase the the connection between the brain and the weak hand muscles. The secondary purpose of this study is to examine changes in weak hand's movement and function after the combined brain, nerve, and hand stimulation. The secondary hypothesis is that the combined brain, nerve, and hand stimulation will increase weak hand movement and function.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 51 (actual)
- First submitted
- 10 Feb 2023
- Start date
- 29 Jun 2023
- Primary completion date
- 21 Dec 2025
- Lead sponsor
- University of Utah
- Diseases
- Stroke
- NCT number
- NCT05736653
What you commit to
- Study type: Interventional
- Participants enrolled: 51
- From 29 Jun 2023 to the primary completion date, 21 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of metallic implants in the head or neck
- Ferromagnetic metallic implants, pacemakers, other implanted devices, or ventilators for magnetic resonance imaging (MRI)
- Participation in concurrent occupational therapy
- Current use of recreational drugs and stimulants like cocaine and methylenedioxymethamphetamine (MDMA)
Other illness
- Diagnosis of neurological disorders other than stroke
- History of seizure or epilepsy
- Orthopedic/musculoskeletal conditions (e.g., arthritis) affecting the upper extremity
- Psychiatric diagnosis according to the criteria of the Diagnostic and Statistical Manual of Mental Disorder, Fifth Edition (DSM-V), or who are on psychotropic medication
Other
- Inability to elicit a motor evoked potential (MEP) in the EDC muscle even with a 20% background muscle contraction
- Presence of severe aphasia
- Excessive spasticity of the wrist and finger muscles, defined as a Modified Ashworth Score \>2
- Currently or planning to become pregnant
- Difficulty maintaining alertness or remaining still
- Bodyweight \> 300 lbs due to MRI scanner dimensions (for subjects also undergoing MRI)
- Life expectancy less than the duration of the study
- Excessive pain in the paretic hand, defined as a Visual Analog Scale Score \>4
Who the study is looking for
- Age between 18-85 years
- Diagnosis of first-ever subcortical stroke (single cerebrovascular accident)
- Stroke onset of at least six months prior to the time of participation
- A score of at least 1 out of 2 on the spherical grasping item of the Fugl-Meyer Upper Extremity Subscale to allow participants to grasp the ball
- Cognitive skills to actively participate, as indicated by scores of \> 23 on the Mini-Mental Status Examination
- English speaking
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Neural Plasticity Rehabilitation and Movement Dynamics Lab Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.