NCT05741957Active, not recruiting
Optimal Exercise Frequency to Reduce Liver Fat in Centrally Obese Adults With Non-Alcoholic Fatty Liver Disease
Examining the Optimal Exercise Frequency for Alleviating Liver Fat in Centrally Obese Adults With Non-Alcoholic Fatty Liver Disease (NAFLD): A Comparative Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 1 May 2026
Brief summary (registry, in English)
This study aims to examine the comparative effectiveness of different exercise frequencies (once-a-week vs. thrice-a-week) for reducing liver fat in centrally obese adults with non-alcoholic fatty liver disease (NAFLD), with weekly exercise volumes aligned with the World Health Organization's physical activity recommendations.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 300 (estimated)
- First submitted
- 13 Feb 2023
- Start date
- 2 Mar 2023
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- The University of Hong Kong
- Diseases
- Obesity, Fatty liver disease (MASLD/MASH)
- NCT number
- NCT05741957
What you commit to
- Study type: Interventional
- Planned participants: 300
- From 2 Mar 2023 to the primary completion date, 30 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Consumption of certain drugs (e.g., tamoxifen and estrogen) known to be secondary causes of steatosis;
- Surgery, therapy, or medication for obesity or weight loss in the past 6 months (e.g., gastric bypass, gastric band, sleeve gastrectomy, gastric reduction duodenal switch, or dietitian-prescribed dietary program);
Other illness
- Medical history of cardiovascular disease, chronic pulmonary or kidney disease, heart failure, cancer, and/or liver disease except NAFLD;
- Somatic conditions that limit exercise participation (e.g., limb loss);
- Impaired mobility due to chronic disease (e.g., chronic arthritis/osteoarthritis, neurological, musculoskeletal, and autoimmune diseases);
- Physical changes that considerably affect body composition and weight (e.g., anorexia nervosa, bulimia nervosa, prolonged gastrointestinal and digestive disorders) during the study period.
Other
- Regular exercise training (\>3 sessions of \>60 min of moderate-intensity exercise training weekly) in the past 6 months;
- Daily smoking habit;
- Excess alcohol consumption (daily ≥20 g of alcohol for men and ≥10 g for women) in the past 1 year;
Who the study is looking for
- Cantonese, Mandarin, or English speaking Chinese;
- Aged 18-69;
- Male or female;
- Centrally obese according to the Asian-specific cut-off (waist circumference ≥90 cm for males; ≥80 cm for females) and with BMI ≥23;
- With NAFLD (defined as \>5% intrahepatic triglycerides assessed by 1H-MRS);
- Willing to participate in exercise training to improve NAFLD.
Age in the registry: 18 years to 69 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| LKS Faculty of Medicine Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.