NCT05742217Completed
A Study to Learn How Patients With Triple Class Refractory Multiple Myeloma (TCR-MM) Are Treated in Italian Centers for Blood Related Diseases
MUltiple Myeloma Italian ObServational sTudy (MUST)
Source: ClinicalTrials.gov · Last updated 9 Jul 2026
Brief summary (registry, in English)
Multiple myeloma (MM) is a type of cancer of the white blood cells, called plasma cells. These plasma cells help in fighting infections. TCR-MM is when the cancer does not get treated with the 3 main classes of medicines used to treat this disease. The purpose of this study is to learn about the present clinical practice in Italy and describe the standard of care that will be given to patients with TCR-MM, and their treatment costs, in around 25 centers who treat patients with blood diseases. Standard of care (SoC) is the treatment that is accepted as a proper treatment for a certain type of disease and that is widely used by doctors. The study is seeking for participants who are: * 18 years of age or older * Confirmed to have MM * do not show any response when treated with the 3 main classes of medicines used to treat MM Data of participants who received the TCR treatment between 01 December 2021 and 31 May will be collected. The main data source for the study will be the patient medical record. No clinical visits, examinations, or procedures are required as part of this study.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 121 (actual)
- First submitted
- 15 Feb 2023
- Start date
- 26 May 2023
- Primary completion date
- 31 May 2026
- Lead sponsor
- Pfizer
- Diseases
- Multiple myeloma
- NCT number
- NCT05742217
What you commit to
- Study type: Observational
- Participants enrolled: 121
- From 26 May 2023 to the primary completion date, 31 May 2026
- 20 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Suffering from any other active malignancy within 3 years prior to enrollment, except for adequately treated basal cell or squamous cell skin cancer or carcinoma in situ
Other illness
- Suffering from active Graft versus host disease (GvHD)
Other
- Suffering from Smoldering MM
- Suffering from Plasma cell leukemia
- Suffering from amyloidosis
- Patients whose first treatment after becoming TCR was part of a clinical trial
- Participation in Elranatamab EAP
Who the study is looking for
- Age ≥18 years
- Diagnosis of MM confirmed using International Myeloma Working Group (IMWG) criteria
- Patients are TCR defined as being refractory to all the 3 following classes: at least 1IMiD, at least 1PI and at least 1 anti-CD38 mA
- Relapsed/refractory to last anti-MM regimen prior to first treatment after TCR
- Started anti-MM treatment after TCR MM eligibility
- Eastern Cooperative Oncology Group (ECOG) performance status ≤2 (at the date of first dose of first treatment after TCR MM eligibility, or no longer than 6 months prior to this date)
- Evidence of a personally signed and dated informed consent document indicating that the patient (or a legally acceptable representative) has been informed of all pertinent aspects of the study. Signed Patient informed consent and Privacy consent documents
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (20)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| A.O.U. Policlinico S.Orsola Malpighi Coordinator of this site? Confirm its status | Bologna | Italy | Unknown status |
| A.O.U Policlinico G. Rodolico S. Marco Coordinator of this site? Confirm its status | Catania | Italy | Unknown status |
| Azienda Ospedaliera Universitaria Careggi Coordinator of this site? Confirm its status | Florence | Italy | Unknown status |
| Clinica di Oncologia Medica Policlinico San Martino Coordinator of this site? Confirm its status | Genova | Italy | Unknown status |
| IRST, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Coordinator of this site? Confirm its status | Meldola (FC) | Italy | Unknown status |
| A.O.U. Policlinico Università degli Studi di Napoli "Federico II" Coordinator of this site? Confirm its status | Naples | Italy | Unknown status |
| Azienda Ospedaliero Universitaria Maggiore della Carità Coordinator of this site? Confirm its status | Novara | Italy | Unknown status |
| A.O.O.R. Villa Sofia Cervello, U.O. Oncoematologia Coordinator of this site? Confirm its status | Palermo | Italy | Unknown status |
| A.O.U. Policlinico Paolo Giaccone Coordinator of this site? Confirm its status | Palermo | Italy | Unknown status |
| Azienda Ospedaliero Universitaria di Parma Coordinator of this site? Confirm its status | Parma | Italy | Unknown status |
| Fondazione IRCCS Policlinico Sa Matteo U.O.C. Ematologia Coordinator of this site? Confirm its status | Pavia | Italy | Unknown status |
| Ospedale Civile dello Spirito Santo Coordinator of this site? Confirm its status | Pescara | Italy | Unknown status |
| Arcispedale Santa Maria Nuova Coordinator of this site? Confirm its status | Reggio Emilia | Italy | Unknown status |
| AUSL della Romagna P.O. Ospedale Infermi U.O. di Oncologia Coordinator of this site? Confirm its status | Rimini | Italy | Unknown status |
| Irccs-Crob Coordinator of this site? Confirm its status | Rionero in Vulture | Italy | Unknown status |
| AOU Policlinico Umberto I Coordinator of this site? Confirm its status | Rome | Italy | Unknown status |
| San Giovanni Di Dio E Ruggi D'Aragona Hospital Coordinator of this site? Confirm its status | Salerno | Italy | Unknown status |
| "IRCCS "" Casa Sollievo della Sofferenza""tOpera di San Pio da Pietrelcina U.O.C di Ematologia" Coordinator of this site? Confirm its status | San Giovanni Rotondo | Italy | Unknown status |
| A.O.U. - Ospedali Riuniti di Ancona Coordinator of this site? Confirm its status | Torrette | Italy | Unknown status |
| Busto Arsizio Hospital Coordinator of this site? Confirm its status | Varese | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.