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NCT05742217Completed

A Study to Learn How Patients With Triple Class Refractory Multiple Myeloma (TCR-MM) Are Treated in Italian Centers for Blood Related Diseases

MUltiple Myeloma Italian ObServational sTudy (MUST)

Source: ClinicalTrials.gov · Last updated 9 Jul 2026

Brief summary (registry, in English)

Multiple myeloma (MM) is a type of cancer of the white blood cells, called plasma cells. These plasma cells help in fighting infections. TCR-MM is when the cancer does not get treated with the 3 main classes of medicines used to treat this disease. The purpose of this study is to learn about the present clinical practice in Italy and describe the standard of care that will be given to patients with TCR-MM, and their treatment costs, in around 25 centers who treat patients with blood diseases. Standard of care (SoC) is the treatment that is accepted as a proper treatment for a certain type of disease and that is widely used by doctors. The study is seeking for participants who are: * 18 years of age or older * Confirmed to have MM * do not show any response when treated with the 3 main classes of medicines used to treat MM Data of participants who received the TCR treatment between 01 December 2021 and 31 May will be collected. The main data source for the study will be the patient medical record. No clinical visits, examinations, or procedures are required as part of this study.

Status (registry)
Completed
Study type
Observational
Enrollment
121 (actual)
First submitted
15 Feb 2023
Start date
26 May 2023
Primary completion date
31 May 2026
Lead sponsor
Pfizer
NCT number
NCT05742217

What you commit to

  • Study type: Observational
  • Participants enrolled: 121
  • From 26 May 2023 to the primary completion date, 31 May 2026
  • 20 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Suffering from any other active malignancy within 3 years prior to enrollment, except for adequately treated basal cell or squamous cell skin cancer or carcinoma in situ

Other illness

  • Suffering from active Graft versus host disease (GvHD)

Other

  • Suffering from Smoldering MM
  • Suffering from Plasma cell leukemia
  • Suffering from amyloidosis
  • Patients whose first treatment after becoming TCR was part of a clinical trial
  • Participation in Elranatamab EAP

Who the study is looking for

  • Age ≥18 years
  • Diagnosis of MM confirmed using International Myeloma Working Group (IMWG) criteria
  • Patients are TCR defined as being refractory to all the 3 following classes: at least 1IMiD, at least 1PI and at least 1 anti-CD38 mA
  • Relapsed/refractory to last anti-MM regimen prior to first treatment after TCR
  • Started anti-MM treatment after TCR MM eligibility
  • Eastern Cooperative Oncology Group (ECOG) performance status ≤2 (at the date of first dose of first treatment after TCR MM eligibility, or no longer than 6 months prior to this date)
  • Evidence of a personally signed and dated informed consent document indicating that the patient (or a legally acceptable representative) has been informed of all pertinent aspects of the study. Signed Patient informed consent and Privacy consent documents

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (20)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
A.O.U. Policlinico S.Orsola Malpighi
Coordinator of this site? Confirm its status
BolognaItalyUnknown status
A.O.U Policlinico G. Rodolico S. Marco
Coordinator of this site? Confirm its status
CataniaItalyUnknown status
Azienda Ospedaliera Universitaria Careggi
Coordinator of this site? Confirm its status
FlorenceItalyUnknown status
Clinica di Oncologia Medica Policlinico San Martino
Coordinator of this site? Confirm its status
GenovaItalyUnknown status
IRST, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
Coordinator of this site? Confirm its status
Meldola (FC)ItalyUnknown status
A.O.U. Policlinico Università degli Studi di Napoli "Federico II"
Coordinator of this site? Confirm its status
NaplesItalyUnknown status
Azienda Ospedaliero Universitaria Maggiore della Carità
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NovaraItalyUnknown status
A.O.O.R. Villa Sofia Cervello, U.O. Oncoematologia
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PalermoItalyUnknown status
A.O.U. Policlinico Paolo Giaccone
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PalermoItalyUnknown status
Azienda Ospedaliero Universitaria di Parma
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ParmaItalyUnknown status
Fondazione IRCCS Policlinico Sa Matteo U.O.C. Ematologia
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PaviaItalyUnknown status
Ospedale Civile dello Spirito Santo
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PescaraItalyUnknown status
Arcispedale Santa Maria Nuova
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Reggio EmiliaItalyUnknown status
AUSL della Romagna P.O. Ospedale Infermi U.O. di Oncologia
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RiminiItalyUnknown status
Irccs-Crob
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Rionero in VultureItalyUnknown status
AOU Policlinico Umberto I
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RomeItalyUnknown status
San Giovanni Di Dio E Ruggi D'Aragona Hospital
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SalernoItalyUnknown status
"IRCCS "" Casa Sollievo della Sofferenza""tOpera di San Pio da Pietrelcina U.O.C di Ematologia"
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San Giovanni RotondoItalyUnknown status
A.O.U. - Ospedali Riuniti di Ancona
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TorretteItalyUnknown status
Busto Arsizio Hospital
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VareseItalyUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.