NCT05743140Recruiting
A Clinical Study of Fundus OCTA for the Identification of CMD
A Clinical Study of Fundus Optical Coherence Tomography Angiography for the Identification of Coronary Microvascular Diseases
Source: ClinicalTrials.gov · Last updated 12 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Coronary microvascular dysfunction (CMD) carries an increased risk of adverse cardiovascular clinical outcomes. The association between fundus microcirculation changes and coronary microcirculation is not well understood. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) is a new type of optical diagnostic imaging technology for non-invasive detection, which can perform multi-dimensional quantitative assessment of fundus microcirculation. In this study, investigators intend to use the coronary angiography-derived index of microvascular resistance (caIMR) to screen patients with CMD, explore the relationship between relevant parameters based on OCT and OCTA measurements and caIMR, and evaluate the feasibility and clinical value of non-invasive identification of CMD through fundus OCT and OCTA.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 7 Feb 2023
- Start date
- 1 Mar 2023
- Primary completion date
- 12 Dec 2025
- Lead sponsor
- Peking University First Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT05743140
What you commit to
- Study type: Observational
- Planned participants: 400
- From 1 Mar 2023 to the primary completion date, 12 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Present serious fundus disease
- Severe cataract and other ophthalmic diseases, which affect imaging quality;
- Active bleeding state;
- Severe renal insufficiency, contrast agent allergy, and unable to perform coronary angiography.
Other
- Target coronary vessels provide collateral circulation for chronic complete occlusive lesions;
- The target coronary angiography agent is poorly filled, overlapped, or severely distorted, and cannot fully expose the location of the lesion;
- Coronary angiography images are of poor quality and cannot be identified;
Who the study is looking for
- Patients who underwent coronary angiography in the Department of Cardiology, Peking University First Hospital;
- Complete baseline clinical information;
- Subject who have coronary angiography results, which shows coronary stenosis \< 50%;
- Older than 18 years;
- Subjects who have signed informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Peking University First Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.