NCT05743829Completed
Atrial Fibrillation Driver Study
Atrial Fibrillation Driver Study - Pilot Project
Source: ClinicalTrials.gov · Last updated 22 Oct 2026
Brief summary (registry, in English)
Atrial Fibrillation (AF) is an abnormal rhythm of the heart which is increasingly common and can be associated with serious consequences. We know that AF is associated with an increase in the scarring of the heart, the left atrium and it is thought that this scarring may be one of the drivers for this abnormal heart rhythm. The nature of this scarring in humans has been subject to limited study and generally only by indirect means such as cardiac MRI scans or measuring the voltage of the tissues. During cardiothoracic surgery, tissue from the left atrium is removed as a part of the procedure. This tissue is normally disposed of, but we would propose to consent patients to collect it to allow it to be analysed. Such analysis would examine the composition of the tissue, including the pattern of scarring, to allow us to gain a greater insight into the mechanisms of AF.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 9 (actual)
- First submitted
- 14 Feb 2023
- Start date
- 4 Jul 2023
- Primary completion date
- 14 May 2025
- Lead sponsor
- University Hospital Southampton NHS Foundation Trust
- Diseases
- Atrial fibrillation
- NCT number
- NCT05743829
What you commit to
- Study type: Observational
- Participants enrolled: 9
- From 4 Jul 2023 to the primary completion date, 14 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Patient unable or unwilling to consent
- Patient not having ostial pulmonary vein or left atrial appendage tissue excised as part of routine clinical care.
Who the study is looking for
- Able to provide informed consent for study
- Male or female subjects between 18 and 100 years of age at the time of consent.
- Thoracic surgical patients either with or without a history of AF undergoing lung resection where an ostial pulmonary vein segment will be excised as part of this resection
- Cardiac surgical patients with a history of AF where surgical LAA exclusion is planned as part of the procedure
Age in the registry: 18 years to 100 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Southampton Coordinator of this site? Confirm its status | Southampton | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.