NCT05757583Active, not recruiting
Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology
Source: ClinicalTrials.gov · Last updated 14 Jul 2026
Brief summary (registry, in English)
This is a single-center study of 80 subjects with asthma including those with obesity and metabolic dysfunction (MD), those with obesity and without metabolic dysfunction, those with severe asthma and mucus plugging and those with severe asthma and without mucus plugging. Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in a cardiopulmonary exercise testing (CPET) visit to compare lung function markers and change in oxygen saturation between obese patients with and without MD and severe asthma patients with and without mucus plugging.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 80 (estimated)
- First submitted
- 23 Feb 2023
- Start date
- 5 Apr 2023
- Primary completion date
- Jun 2027
- Lead sponsor
- University of California, San Francisco
- Diseases
- Asthma
- NCT number
- NCT05757583
What you commit to
- Study type: Observational
- Planned participants: 80
- From 5 Apr 2023 to the primary completion date, Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Asthma exacerbation or URI within the previous 6 weeks.
Age
- History of smoking
- If \<30 years old: Smoked for ≥5 pack-years
- If ≥30: Smoked for ≥10 pack years
Other
- Pregnancy
- Absolute or relative contraindication to exercise testing per ATS criteria
- Any other criteria that place the subject at unnecessary risk according to the judgment of the Principal Investigator and/or attending physician of record.
Who the study is looking for
- Male or female ≥ 18 years old at Visit 0
- Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
- History of physician diagnosed asthma
- Evidence of bronchodilator reversibility (12% improvement in FEV1 after albuterol administration) or positive methacholine challenge PC20 or PD20. Historical evidence is accepted.
- Meets criteria for obesity or severe asthma a. Obesity: BMI≥30 i. Metabolic dysfunction is defined as presence of either:
- 1\. IL-6 high: Plasma IL-6 \> 3.0 pg/mL 2. Insulin resistance: HOMA-IR \> 3 mass units b. Severe asthma: Requires treatment with high dose inhaled corticosteroids plus a second controller, systemic corticosteroid, or biologic therapy.
- Mucus Plugging is defined as mucus plug score ≥ 4
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UCSF Airway Clinical Research Center Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.