NCT05762679Completed
Quantifying Myofascial Dysfunction in Post-Stroke Pain
Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management
Source: ClinicalTrials.gov · Last updated 9 Jul 2025
Brief summary (registry, in English)
The purpose of this study is to quantify the extent of GlycosAminoGlycan/Hyaluronic Acid (GAG/HA) accumulation using T1rho (T1ρ) MRI in the paretic versus non-paretic shoulder rotator muscles, and correlate the T1ρ Magnetic Resonance Imaging (MRI) measurements with US echo texture measurements to develop a clinic-friendly tool to infer the extent of HA accumulation; and to distinguish between latent versus active Post Stroke Shoulder Pain (PSSP) using ultrasound (US) shear strain mapping of the same muscles on the paretic side compared with the non-paretic side.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 46 (actual)
- First submitted
- 28 Feb 2023
- Start date
- 28 Feb 2023
- Primary completion date
- 24 May 2024
- Lead sponsor
- Johns Hopkins University
- Diseases
- Stroke
- NCT number
- NCT05762679
What you commit to
- Study type: Interventional
- Participants enrolled: 46
- From 28 Feb 2023 to the primary completion date, 24 May 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Received treatment for spasticity with Botulinum Toxin or Intrathecal Baclofen within the past three months
Other illness
- Have another neurologic condition that may affect motor response (e.g. Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS))
- Have non-musculoskeletal PSSP such as only central pain or Chronic Regional Pain Syndrome (CRPS)
- Have a complicated medical condition, or significant injury to either upper limb.
Other
- Have a contraindication to MRI (claustrophobia, magnetic pacemakers and clips)
Who the study is looking for
- 18 years or older
- Hemiparesis from Ischemic or Hemorrhagic Stroke
- 4-120 months post-stroke with Hemiparesis since the incidence and intensity of PSSP
- Show a difference of more than 10 degrees of passive ER-ROM between non-paretic and paretic shoulders with or without pain
- Able to provide informed consent and comply with testing protocols
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins University School Of Medicine Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.