NCT05766059Recruiting
Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation
Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation: Cross-modal Paired Associative Stimulation (PAS) Protocols to Promote Plastic Reorganization in Stroke and Phantom Limb Pain Patients
Source: ClinicalTrials.gov · Last updated 17 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Paired associative stimulation (PAS) is a non-invasive brain stimulation protocol, where two stimuli (a peripheral and a cortical one, the latter delivered with transcranial magnetic stimulation - TMS) are repeatedly associated to enhance plasticity in the brain. In the present study, a new cross-modal, visuo-motor PAS protocol - called "mirror-PAS"- will be tested as a possible non-invasive brain stimulation treatment in neurological rehabilitation to promote motor recovery and pain reduction. Participants will perform the standard PAS targeting the motor system and the recently developed mirror-PAS in two separate sessions. The investigators will compare the possible effect of the protocols in terms of neurophysiological and behavioral outcomes to identify the optimal PAS method to enhance plasticity and promote sensory-motor function.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 36 (estimated)
- First submitted
- 28 Feb 2023
- Start date
- 8 Feb 2023
- Primary completion date
- 30 Sept 2026
- Lead sponsor
- Istituto Auxologico Italiano
- Diseases
- Stroke
- NCT number
- NCT05766059
What you commit to
- Study type: Interventional
- Planned participants: 36
- From 8 Feb 2023 to the primary completion date, 30 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- other neurological conditions (e.g., Parkinson's Disease, Multiple Sclerosis, ALS)
- other orthopedic condition that affected the hand (e.g., carpal tunnel syndrome)
- other neurological, orthopedical or psychiatric conditions
Other
- contraindications to TMS (Rossi et all, 2021)
- contraindications to TMS (Rossi et all, 2021)
Who the study is looking for
- age from 18 to 85 years
- single, unilateral, hemispheric stroke (cortical or sub-cortical areas)
- stroke confirmed by neuroimaging (CT or MRI)
- stroke at least 4 months before enrollment
- hemiparesis of the upper limb resulting from stroke or hemianesthesia clinically documented
- age from 18 to 90 years
- amputation of one part of the upper limb at least 2 months before enrollment
- presence of stable phantom limb pain at least 2 months prior to enrollment
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istituto Auxologico Italiano IRCCS Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.