NCT05767021CompletedPhase 3
A Study of Mirikizumab (LY3074828) in Participants With Moderately to Severely Active Ulcerative Colitis
A Multicenter, Phase 3b, Open-Label, Single-Arm Study to Investigate Bowel Urgency and Its Relationship With Other Outcome Measures in Adults With Moderately to Severely Active Ulcerative Colitis Treated With Mirikizumab
Source: ClinicalTrials.gov · Last updated 10 Jun 2026
Brief summary (registry, in English)
A study to investigate bowel urgency in adults with moderately to severely active ulcerative colitis (UC) treated with mirikizumab. The study will have 4 periods and will last for 36 weeks.
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 172 (actual)
- First submitted
- 8 Feb 2023
- Start date
- 17 May 2023
- Primary completion date
- 9 Aug 2024
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Ulcerative colitis
- NCT number
- NCT05767021
- EU CT number
- 2022-502393-16-00
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 172
- From 17 May 2023 to the primary completion date, 9 Aug 2024
- 116 sites in 11 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Have Crohn's disease (CD)
- Have inflammatory bowel disease-unclassified, formerly known as indeterminate colitis, or
- Have ulcerative proctitis, disease limited to the rectum, that is, distal to the recto-sigmoid junction, which lies approximately 10 to 15 centimeter (cm) from anal verge.
- Have an inherited immunodeficiency syndrome or a monogenic cause of UC-like colonic inflammation
- Have any history or current evidence of cancer of the gastrointestinal tract
- Have active tuberculosis
- Have HIV infection.
Who the study is looking for
- Have an established diagnosis of UC for ≥3 months
- Have confirmed diagnosis of moderately for severely active UC
- Have current bowel urgency
- Have demonstrated an inadequate response to, a loss of response to, or an intolerance to conventional or to biologic/Janus Kinase (JAK) inhibitor/sphingosine-1-phosphate (S1P) receptor modulator therapy for UC.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (116)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medizinische Universitaet Innsbruck Coordinator of this site? Confirm its status | Innsbruck | Austria | Completed |
| Gemeinnutzige Salzburger Landes kliniken Betriebsgesellschaft mbH Coordinator of this site? Confirm its status | Salzburg | Austria | Completed |
| Medical University of Vienna Coordinator of this site? Confirm its status | Vienna | Austria | Completed |
| Krankenhaus Barmherzige Schwestern Wien Coordinator of this site? Confirm its status | Wien | Austria | Completed |
| Universitair Ziekenhuis Gent Coordinator of this site? Confirm its status | Gent | Belgium | Completed |
| UZ Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Completed |
| SurGal Clinic s.r.o. Coordinator of this site? Confirm its status | Brno-Sever | Czechia | Completed |
| Vojenska Nemocnice Brno Coordinator of this site? Confirm its status | Brno-Zidenice | Czechia | Completed |
| GASTRO JeKa s.r.o. Coordinator of this site? Confirm its status | Klatovy IV | Czechia | Completed |
| Hepato-Gastroenterologie HK s.r.o. Coordinator of this site? Confirm its status | Novy Hradec Kralove | Czechia | Completed |
| PreventaMed, s.r.o. Coordinator of this site? Confirm its status | Olomouc | Czechia | Completed |
| University Hospital Ostrava Coordinator of this site? Confirm its status | Poruba | Czechia | Completed |
| DRK Kliniken Berlin Coordinator of this site? Confirm its status | Berlin | Germany | Completed |
| Gastroenterologische Spezialpraxis Coordinator of this site? Confirm its status | Berlin | Germany | Completed |
| University Hospital Halle (Saale) Coordinator of this site? Confirm its status | Halle Saale | Germany | Completed |
| Hamburgisches Forschungsinstitut fuer chronisch entzuendliche Darmerkrankungen HaFCED e.K. Coordinator of this site? Confirm its status | Hamburg | Germany | Completed |
| Universitaet Leipzig Coordinator of this site? Confirm its status | Leipzig | Germany | Completed |
| Besancon University Hospital Center Coordinator of this site? Confirm its status | Besancon Cedex | France | Completed |
| Centre Hospitalier Universitaire De Lille Coordinator of this site? Confirm its status | Lille Cedex | France | Completed |
| Hopital Saint Eloi Coordinator of this site? Confirm its status | Montpellier Cedex 5 | France | Completed |
| Centre Hospitalier Universitaire de Nantes Coordinator of this site? Confirm its status | Nantes | France | Completed |
| Clinique Jules Verne Coordinator of this site? Confirm its status | Nantes | France | Completed |
| Centre Hospitalier Universitaire de Nice Coordinator of this site? Confirm its status | Nice | France | Completed |
| Centre Hospitalier De Pau Coordinator of this site? Confirm its status | Pau Cedex | France | Completed |
| Centre Hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Pessac | France | Completed |
| Hospices Civils de Lyon Coordinator of this site? Confirm its status | Pierre-Bénite | France | Completed |
| Centre Hospitalier Universitaire De Reims Coordinator of this site? Confirm its status | Reims Cedex | France | Completed |
| Centre Hospitalier Universitaire de Rennes Coordinator of this site? Confirm its status | Rennes | France | Completed |
| Centre Hospitalier Universitaire de Saint Etienne Coordinator of this site? Confirm its status | Saint-Priest-en-Jarez | France | Completed |
| CHRU De Nancy Coordinator of this site? Confirm its status | Vandoeuvre Les Nancy | France | Completed |
| Fairfield General Hospital Coordinator of this site? Confirm its status | Bury | United Kingdom | Unknown status |
| King's College Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Clinical Research Unit, Royal Liverpool University Hospital Coordinator of this site? Confirm its status | Waltham | United Kingdom | Unknown status |
| Bekes Megyei Kozponti Korhaz Coordinator of this site? Confirm its status | Békéscsaba | Hungary | Completed |
| Clinexpert Kft. Coordinator of this site? Confirm its status | Budapest III | Hungary | Completed |
| Semmelweis University Coordinator of this site? Confirm its status | Budapest VIII | Hungary | Completed |
| Pannonia Maganorvosi Centrum Kft. Coordinator of this site? Confirm its status | Budapest XIII | Hungary | Completed |
| University of Debrecen Coordinator of this site? Confirm its status | Debrecen | Hungary | Completed |
| Bugat Pal Korhaz Kht. Coordinator of this site? Confirm its status | Gyongyos | Hungary | Completed |
| Clinfan Kft. Coordinator of this site? Confirm its status | Szekszard | Hungary | Completed |
| Javorszky Odon Korhaz Coordinator of this site? Confirm its status | Vác | Hungary | Completed |
| National Institute of Gastroenterology Saverio De Bellis Research Hospital Coordinator of this site? Confirm its status | Castellana Grotte | Italy | Completed |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Coordinator of this site? Confirm its status | Milan | Italy | Completed |
| Ospedale San Raffaele S.r.l. Coordinator of this site? Confirm its status | Milan | Italy | Completed |
| Azienda Ospedaliera Policlinico Universitario Tor Vergata Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| Humanitas Research Hospital Coordinator of this site? Confirm its status | Rozzano | Italy | Completed |
| Azienda Ospedaliera Ordine Mauriziano di Torino Coordinator of this site? Confirm its status | Turin | Italy | Completed |
| Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j. Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Completed |
| Topolowa Medicenter Ryszawa & Wspolnicy Sp. j. Coordinator of this site? Confirm its status | Cracow | Poland | Completed |
| Economicus Sp. z o.o. Coordinator of this site? Confirm its status | Katowice | Poland | Completed |
| MZ Badania Slowik Zymla Sp.j. Coordinator of this site? Confirm its status | Knurów | Poland | Completed |
| Med Gastr Sp.z.o.o Sp.k Coordinator of this site? Confirm its status | Lodz | Poland | Completed |
| Amicare Sp. z o.o. S.K. Coordinator of this site? Confirm its status | Lodz | Poland | Completed |
| Twoja Przychodnia Opolskie Centrum Medyczne Coordinator of this site? Confirm its status | Opole | Poland | Completed |
| Nowe Zdrowie-CK Kieltucki I Wspolnicy Sp. j. Coordinator of this site? Confirm its status | Staszów | Poland | Completed |
| Twoja Przychodnia-Szczecinskie Centrum Medyczne Sp. z o. o. Coordinator of this site? Confirm its status | Szczecin | Poland | Completed |
| Sonomed Sp. z o.o. Coordinator of this site? Confirm its status | Szczecin | Poland | Completed |
| NZOZ FOR MED sp. z o.o. Coordinator of this site? Confirm its status | Wadowice | Poland | Completed |
| Centrum Medyczne Oporow Coordinator of this site? Confirm its status | Wroclaw | Poland | Completed |
| PlanetMed Sp. z o.o. Coordinator of this site? Confirm its status | Wroclaw | Poland | Completed |
| Futuremeds Sp. z o.o. Coordinator of this site? Confirm its status | Wroclaw | Poland | Completed |
| Centrum Medyczne Kuba-Med 2 Sp. z o.o. Coordinator of this site? Confirm its status | Zamosc | Poland | Completed |
| Cliniq s.r.o. Coordinator of this site? Confirm its status | Bratislava | Slovakia | Completed |
| ENDOMED, s.r.o. Coordinator of this site? Confirm its status | Košice | Slovakia | Completed |
| KM Management spol. s r.o. Coordinator of this site? Confirm its status | Nitra | Slovakia | Completed |
| Accout Center s.r.o. Coordinator of this site? Confirm its status | Šahy | Slovakia | Completed |
| Digestive Health Partners - Research Department Coordinator of this site? Confirm its status | Asheville | United States | Unknown status |
| Digestive Healthcare of Georgia Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Washington Gastroenterology Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| NY Scientific Coordinator of this site? Confirm its status | Brooklyn | United States | Unknown status |
| Charlotte Gastroenterolgy & Hepatology Coordinator of this site? Confirm its status | Charlotte | United States | Unknown status |
| Charlottesville Medical Research Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
| Clinical Research Institute of Michigan, LLC Coordinator of this site? Confirm its status | Chesterfield | United States | Unknown status |
| Chevy Chase Clinical Research Coordinator of this site? Confirm its status | Chevy Chase | United States | Unknown status |
| Central Florida Gastro Research Coordinator of this site? Confirm its status | Clearwater | United States | Unknown status |
| Optimed Research, LTD Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Gastro One Coordinator of this site? Confirm its status | Cordova | United States | Unknown status |
| Atlanta Center For Gastroenterology, P.C. Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Medical Research Center of Connecticut, LLC Coordinator of this site? Confirm its status | Hamden | United States | Unknown status |
| Houston Endoscopy And Research Center, LLC Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Clinical Trial Network Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Biopharma Informatic, LLC Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Grand Teton Research Group, PLLC Coordinator of this site? Confirm its status | Idaho Falls | United States | Unknown status |
| IU Health University Hospital Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| ENCORE Borland Groover Clinical Research Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Citrine Institute for Research and Wellness Coordinator of this site? Confirm its status | Katy | United States | Unknown status |
| Tri-Cities Gastroenterology Coordinator of this site? Confirm its status | Kingsport | United States | Unknown status |
| Om Research LLC Coordinator of this site? Confirm its status | Lancaster | United States | Unknown status |
| Dedicated Clinical Research Coordinator of this site? Confirm its status | Litchfield Park | United States | Unknown status |
| AngioCardiac Care of Texas, PA Coordinator of this site? Confirm its status | McAllen | United States | Unknown status |
| GI Alliance/ Metairie Coordinator of this site? Confirm its status | Metairie | United States | Unknown status |
| Research Associates of South Florida Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Advanced Research Associates, LLC Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Paramount Medical Research & Consulting, LLC Coordinator of this site? Confirm its status | Middleburg Heights | United States | Unknown status |
| Delta Research Partners Coordinator of this site? Confirm its status | Monroe | United States | Unknown status |
| Gastroenterology Health Partners Coordinator of this site? Confirm its status | New Albany | United States | Unknown status |
| Central Sooner Research Coordinator of this site? Confirm its status | Norman | United States | Unknown status |
| California Medical Research Associates Inc. Coordinator of this site? Confirm its status | Northridge | United States | Unknown status |
| Care Access Research, Ogden Coordinator of this site? Confirm its status | Ogden | United States | Unknown status |
| Digestive System Healthcare Coordinator of this site? Confirm its status | Pasadena | United States | Unknown status |
| Linq Research, LLC Coordinator of this site? Confirm its status | Pearland | United States | Unknown status |
| University Gastroenterology Coordinator of this site? Confirm its status | Providence | United States | Unknown status |
| Southern Star Research Institute, LLC Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Gastroenterology Research of San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Clinical Applications Laboratories, Inc. Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| Gastroenterology Associates of Texas - Denise Rodriguez Coordinator of this site? Confirm its status | Sugar Land | United States | Unknown status |
| Arizona Digestive Health - Sun City Coordinator of this site? Confirm its status | Sun City | United States | Unknown status |
| Washington Gastroenterology dba GI Alliance Coordinator of this site? Confirm its status | Tacoma | United States | Unknown status |
| International Center for Research LLC Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| GCP Clinical Research, LLC Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Cotton-O'Neil Clinical Research Center, Digestive Health Coordinator of this site? Confirm its status | Topeka | United States | Unknown status |
| Tyler Research Institute, LLC Coordinator of this site? Confirm its status | Tyler | United States | Unknown status |
| GI Alliance Research Webster Coordinator of this site? Confirm its status | Webster | United States | Unknown status |
| Innovo Research:Wilmington Health Coordinator of this site? Confirm its status | Wilmington | United States | Unknown status |
| West Michigan Clinical Research Center Coordinator of this site? Confirm its status | Wyoming | United States | Unknown status |
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This page is information, not medical advice. Discuss any trial with your doctor.