NCT05767177Completed
Jejunal Ketogenesis and Type 2 Diabetes
Small Intestinal Ketogenesis - Potential Significance for Type 2 Diabetes in Obesity
Source: ClinicalTrials.gov · Last updated 25 Apr 2025
Brief summary (registry, in English)
The goal of this cross-over study in obese subjects is to learn about the common co-morbidity type 2 diabetes and the local formation of ketone bodies. The type of study is an exploratory trial with the participants as own controls. The main questions it aims to answer are: 1. Does food intake-induced ketogenesis exist in the small intestine of obese individuals? 2. Are insulin resistance, the incretin GLP-1 release and the glucose transporter SGLT1 affected in obese individuals without type 2 diabetes in the same way as those with type 2 diabetes?
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 12 (actual)
- First submitted
- 16 Feb 2023
- Start date
- 1 Jun 2023
- Primary completion date
- 19 Apr 2025
- Lead sponsor
- Göteborg University
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT05767177
What you commit to
- Study type: Interventional
- Participants enrolled: 12
- From 1 Jun 2023 to the primary completion date, 19 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Sequelae of previous diabetes-associated disease (foot, eyes and kidneys, or cardiovascular incident, etc.)
- Preferably otherwise medication-free (exceptions can be made)
- Previously known organic gastrointestinal disease, except for gastroesophageal reflux disease (GERD)
Other illness
- Insulin-treated diabetes
- Diabetes, hypertension, lipid disorder that has not been stabilized for at least 1 month by adequate pharmacological treatment
- History of drug abuse or other circumstances deemed to jeopardize the patient's ability to participate in the research project
Other
- Continuous NSAID use
- Not operated on in the abdomen (appendectomy excluded)
- Smokers
- Pregnancy and breastfeeding
Who the study is looking for
- BMI 35 to 45 kg/m2
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Dept of Surgery, Sahlgrenska Universityhospital Coordinator of this site? Confirm its status | Gothenburg | Sweden | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.