NCT05772702Completed
Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Depression
Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Depression (CLACS): Single-Site Open-Label Pilot Study
Source: ClinicalTrials.gov · Last updated 29 May 2025
Brief summary (registry, in English)
The purpose of this research study is to study closed-loop transcranial alternating current stimulation (tACS) to determine its effects on symptoms of depression in people with major depressive disorder.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 26 (actual)
- First submitted
- 24 Feb 2023
- Start date
- 13 Feb 2023
- Primary completion date
- 22 Apr 2024
- Lead sponsor
- Electromedical Products International, Inc.
- Diseases
- Depression
- NCT number
- NCT05772702
What you commit to
- Study type: Interventional
- Participants enrolled: 26
- From 13 Feb 2023 to the primary completion date, 22 Apr 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- DSM-5 diagnosis of severe alcohol use disorder (AUD) within the last 12 months.
- DSM-5 diagnosis of moderate to severe substance use disorder (excluding tobacco) within the last 12 months.
- Lifetime history of bipolar disorder, psychotic disorder, schizophrenia, autism
Other
- Current use of benzodiazepines \> 20mg diazepam/d equivalent
- Antidepressant dose change within the last 2 weeks
- Initiated new antidepressant within the last 4 weeks
Who the study is looking for
- Ages 18-70 years
- Diagnostic and Statistical Manual, 5th Edition (DSM-5) diagnosis of MDD; unipolar, non-psychotic
- Hamilton Rating Depression Rating Scale (HRDS-17) score \>8
- Low suicide risk as determined by the Columbia-Suicide Severity Rating Scale (C-SSRS) triage form (no intent or plan)
- Capacity to understand all relevant risks and potential benefits of the study (informed consent)
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Carolina Center for Neurostimulation Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.