NCT05774704RecruitingPhase 1/2
Curcumin and Retinal Study
Curcumin and Retinal Amyloid-beta Pilot Study
Source: ClinicalTrials.gov · Last updated 13 Jan 2026
Brief summary (registry, in English)
To test how two weeks of curcumin supplementation would cross the blood brain barrier (BBB) and attach to amyloid beta proteins, to assess the feasibility (safety and bioavailability), and to explore the resulting abundance/composition of gut microbiota.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 23 Feb 2023
- Start date
- 21 Aug 2023
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Texas Tech University Health Sciences Center
- NCT number
- NCT05774704
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 60
- From 21 Aug 2023 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Inclusion:
- Both male and female, age 40 - 89 years.
- Diagnosed with Aβ deposits in retina (peripheral superior quadrants)--to be confirmed after consent obtained. If there is documentation the potential participant has been diagnosed with Aβ deposits in retina within 6 months before the consent session, we will use this diagnosis/documentation for eligibility criteria. Otherwise, the ophthalmic exam will be repeated after consent is obtained for the study.
- No pre-existing liver or kidney diseases by self-report.
- Exclusion:
- Patients with ocular diseases (macular degeneration, severe diabetes retinopathy)
- Had used systemic antibiotics within 1 month prior to the start of the study intervention
- Had taken any turmeric or curcumin products within 2 weeks prior to the start of the study intervention
- Had a known allergy to black pepper
- Women that are pregnant or breastfeeding
Age in the registry: 40 years to 89 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Texas Tech University Health Sciences Center Coordinator of this site? Confirm its status | Lubbock | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.