NCT05775588Recruiting
Long-term Effects of Endobronchial Valve Implantation on Cardiac Function and Skeletal Muscle Function
Long-term Effects of Endobronchial Valve Implantation on Cardiac Function and Skeletal Muscle Function in Patients With Lung Volume Reduction Surgery
Source: ClinicalTrials.gov · Last updated 5 Oct 2026
Brief summary (registry, in English)
The goal of this type of study: clinical trial is to evaluate the effect of bronchial valve implantation on cardiac function and skeletal muscle function in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:evaluate the effect of bronchial valve implantation on cardiac function and skeletal muscle function. Participants will undergo Lung volume reduction surgery with endobronchial valve implantation.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 23 Feb 2023
- Start date
- 27 Mar 2023
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- China-Japan Friendship Hospital
- Diseases
- COPD
- NCT number
- NCT05775588
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 27 Mar 2023 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- More than 3 hospitalizations for pulmonary infection in the past 12 months before baseline assessment
- Previous lobectomy, LVRS or lung transplantation
- Anticoagulant therapy that cannot be stopped before surgery
- Participated in other lung drug studies within the first 30 days of this study
Other illness
- Obvious chronic bronchitis, bronchiectasis or other infectious pulmonary diseases
- Any disease or condition that interferes with the completion of the initial or subsequent assessment
Lab values
- LVEF\<45% and or RVSP\>50mmHg
Other
- PaCO2\>8.0 kPa, or PaO2\<6.0 kPa
- 6-minute walk test\<160m
- Patients with obvious immune deficiency
- Pulmonary nodules requiring intervention
Who the study is looking for
- Patients with Chronic Obstructive Pulmonary Disease
- FEV1 ≤ 45% pred and FEV1/FVC\<70%
- TLC\>100% pred and RV\>175% pred
- CAT score≥18
- Emphysema damage\>50%
- Complete interlobar fissure \>95% based on quantitative analysis of CT measurement
- No smoking\>6 months
- Sign the informed consent form
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| China-Japan Friendship Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.