NCT05779631Recruiting
Multi-parametric MRI in Patients Suspected for Muscle Invasive Bladder Cancer: a New Local Staging Paradigm
Multi-parametric MRI in Patients Suspected for Muscle Invasive Bladder Cancer: a New Local Staging Paradigm (BladParadigm)
Source: ClinicalTrials.gov · Last updated 8 Jan 2026
Brief summary (registry, in English)
A two-arm multicenter randomised controlled trial, comparing progression free survival, time to definitive treatment and cost-effectiveness of the standard of care (TURBT) and mpMRI followed by same-day cystoscopic bladder biopsy for diagnosis of patients with suspicion of muscle-invasive bladder cancer.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 360 (estimated)
- First submitted
- 9 Mar 2023
- Start date
- 6 Dec 2023
- Primary completion date
- Dec 2028
- Lead sponsor
- Radboud University Medical Center
- Diseases
- Bladder cancer
- NCT number
- NCT05779631
What you commit to
- Study type: Interventional
- Planned participants: 360
- From 6 Dec 2023 to the primary completion date, Dec 2028
- 19 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Unfit for definitive treatment with curative intent
Age
- A history of cancer, including bladder cancer, except: non-melanoma skin cancer, prostate cancer on active surveillance or a solid malignant tumor ≥5 years disease-free since last treatment
Other
- Unable or unwilling to undergo mpMRI
- Unfit for TURBT
Who the study is looking for
- Patients (18+ years of age)
- Clinically suspected MIBC
- No lymph node or distant metastases
- Written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (19)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ziekenhuisgroep Twente Coordinator of this site? Confirm its status | Almelo | Netherlands | Recruiting |
| Meander MC Coordinator of this site? Confirm its status | Amersfoort | Netherlands | Not yet recruiting |
| OLVG Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Amsterdam UMC, location AMC Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Antoni van Leeuwenhoek - Netherlands Cancer Institute Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Amsterdam UMC location VUmc Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Rijnstate Ziekenhuis Coordinator of this site? Confirm its status | Arnhem | Netherlands | Recruiting |
| Maasziekenhuis Pantein Coordinator of this site? Confirm its status | Boxmeer | Netherlands | Recruiting |
| Ziekenhuis Gelderse Vallei Coordinator of this site? Confirm its status | Ede | Netherlands | Recruiting |
| Treant Coordinator of this site? Confirm its status | Emmen | Netherlands | Not yet recruiting |
| Medisch Spectrum Twente Coordinator of this site? Confirm its status | Enschede | Netherlands | Not yet recruiting |
| St. Antonius Ziekenhuis Coordinator of this site? Confirm its status | Nieuwegein | Netherlands | Recruiting |
| Canisius Wilhelmina Ziekenhuis Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Recruiting |
| Radboud University Medical Center Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Recruiting |
| Erasmus Medical Center Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Not yet recruiting |
| Jeroen Bosch Ziekenhuis Coordinator of this site? Confirm its status | 's-Hertogenbosch | Netherlands | Recruiting |
| Bernhoven Ziekenhuis Coordinator of this site? Confirm its status | Uden | Netherlands | Recruiting |
| University Medical Center Utrecht Coordinator of this site? Confirm its status | Utrecht | Netherlands | Recruiting |
| VieCuri Medisch Centrum Coordinator of this site? Confirm its status | Venlo | Netherlands | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.