NCT05781087Active, not recruiting
Predicting the Risk of Non-culprit Coronary Artery Disease After a Heart Attack
Optical Coherence Tomography With Magnetic Resonance Angiography to Assess STEMI Non-culprit Risk
Source: ClinicalTrials.gov · Last updated 16 Jun 2026
Brief summary (registry, in English)
Heart attacks caused by the complete blockage of a heart artery are treated by opening it with a stent. However, most people will also have 'non-culprit' narrowings found in their other arteries at this time. Although in general people do better if these non-culprit narrowings are also treated with stents if they look severe, this process has problems. This is because narrowings that look severe may be stable and not cause any trouble. For these people a stent is a wasted procedure and unnecessary risk. On the other hand, narrowings that are currently left alone because they appear mild, may progress and cause a heart attack. Participants who have had a heart attack will have a scan from inside the heart arteries during an angiogram (optical coherence tomography, OCT) and a magnetic resonance angiogram (MRA). If the investigators can show that it is possible to accurately predict which non-culprit narrowings are going to progress and which are going to stabilise, medical professionals may be able to better target their treatments after a heart attack.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 90 (actual)
- First submitted
- 9 Mar 2023
- Start date
- 25 Apr 2023
- Primary completion date
- 1 Jul 2026
- Lead sponsor
- Guy's and St Thomas' NHS Foundation Trust
- Diseases
- Coronary artery disease
- NCT number
- NCT05781087
What you commit to
- Study type: Observational
- Participants enrolled: 90
- From 25 Apr 2023 to the primary completion date, 1 Jul 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior coronary artery bypass grafting
Lab values
- Creatinine clearance \<30ml/min
Other
- Cardiogenic shock requiring intubation, inotropes or a mechanical support device
- Life expectancy less than 3 years
- Pregnancy.
- Target lesion in the left main coronary artery
- Severe calcification or tortuosity that would threaten safe placement of a pressure wire or OCT catheter
- Chronic total occlusion of a major epicardial vessel.
Who the study is looking for
- Successful primary percutaneous coronary intervention (PCI) within the previous week with no major complications at the index procedure
- Bystander disease in a non-culprit vessel planned for clinically indicated staged angiography +/- PCI
- Able to provide written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Royal Bournemouth Hospital Coordinator of this site? Confirm its status | Bournemouth | United Kingdom | Unknown status |
| King's College Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| St Thomas Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.