NCT05781321Active, not recruitingPhase 2
Short Course Radiotherapy for the Treatment of Patients With Glioblastoma, SAGA Study
Stereotactic Accelerated Radiotherapy in GlioblastomA (SAGA)
Source: ClinicalTrials.gov · Last updated 30 Jul 2026
Brief summary (registry, in English)
This phase II trial compares the effect of short course radiotherapy (RT) to standard course RT for the treatment of patients diagnosed with glioblastoma (GBM). The researchers want to learn whether the shorter course treatment is non-inferior (not worse than the standard of care), for patients with GBM. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Short course radiotherapy delivers higher doses of radiation over a shorter period of time and may kill more tumor cells and have fewer side effects.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 170 (estimated)
- First submitted
- 27 Feb 2023
- Start date
- 23 Mar 2023
- Primary completion date
- 30 Nov 2026
- Lead sponsor
- Mayo Clinic
- Diseases
- Glioblastoma
- NCT number
- NCT05781321
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 170
- From 23 Mar 2023 to the primary completion date, 30 Nov 2026
- 8 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous brain radiation therapy
- Patients who will not receive any radiation treatment or who will receive radiation treatment elsewhere (Note: radiotherapy can be given on the trial at Mayo Clinic facilities in Rochester, Arizona, or Florida, as well as at the Mayo Clinic Health System sites). Temozolomide, however, can be provided by another institution
Other illness
- Unable to undergo an 18F-DOPA-PET scan (e.g., Parkinson's Disease, taking carbidopa/levodopa and/or less than 48 hours from discontinuance)
Other
- Unable to undergo MRI scans with contrast
- Any of the following:
- Pregnant women
- Nursing women
- Men or women of childbearing potential who are unwilling to employ adequate contraception
- Tumors with IDH mutation
Who the study is looking for
- Age \>= 18 years
- Histological and/or molecular confirmation of glioblastoma
- Eastern Oncology Group (ECOG) performance status (PS) =\< 3
- Ability to complete questionnaire(s) by themselves or with assistance
- Provide written informed consent or have a legally authorized representative (LAR) who is responsible for the care and well-being of the potential study participant, provide consent
- Willing to return to enrolling institution for follow-up either in-person or by video visit
- Postoperative/post-biopsy tumor plus surgical bed size =\< 6 cm in maximum diameter. This measurement includes both the enhancing region identified via T1 MRI with contrast, as well as the surgical cavity
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic Health System in Albert Lea Coordinator of this site? Confirm its status | Albert Lea | United States | Unknown status |
| Mayo Clinic Health System-Eau Claire Coordinator of this site? Confirm its status | Eau Claire | United States | Unknown status |
| Mayo Clinic in Florida Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Mayo Clinic Health System-Franciscan Healthcare Coordinator of this site? Confirm its status | La Crosse | United States | Unknown status |
| Mayo Clinic Health Systems-Mankato Coordinator of this site? Confirm its status | Mankato | United States | Unknown status |
| Mayo Clinic Radiation Therapy - Northfield Coordinator of this site? Confirm its status | Northfield | United States | Unknown status |
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Mayo Clinic in Arizona Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.