NCT05781711CompletedPhase 2
Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
Parkinson's disease (PD) is one of the most common neurodegenerative diseases characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra compacta (SNc) and aggregation of Lewy bodies in neurons. Although aging, oxidative damage and neuroinflammation have been recognized to play crucial roles in the pathogenesis of PD, the precise etiology remains obscure. Emerging evidence suggests PD is a systemic metabolic disease, and metabolic abnormality correlates with functional alternations in PD
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 11 Mar 2023
- Start date
- 6 Jun 2023
- Primary completion date
- 20 Aug 2024
- Lead sponsor
- Tanta University
- Diseases
- Parkinson disease
- NCT number
- NCT05781711
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 60
- From 6 Jun 2023 to the primary completion date, 20 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Secondary causes of Parkinsonism Diabetic patients Patients taking anti-inflammatory drugs Atypical parkinsonian syndromes Prior stereotaxic surgery for Parkinson's disease Pregnancy and lactation Suffering from active malignancy Addiction to alcohol and/or drugs Known allergy to the studied medications
Who the study is looking for
- Age ≥ 50 years Both males and females will be included Negative pregnancy test and effective contraception. Diagnosed Parkinson's disease patient taking Levodopa
Age in the registry: 50 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Medicine, Menoufia University Coordinator of this site? Confirm its status | Tanta | Egypt | Unknown status |
Related publications
- Randomized, double-blind, placebo-controlled pilot study of metformin as an adjunctive therapy in Parkinson's disease.Front Pharmacol · 2025 · PMID 40385486
This page is information, not medical advice. Discuss any trial with your doctor.