NCT05785221Active, not recruiting
Energy Metabolism Profiles Over Weight-loss and Eating Responses
Exploratory Personalized Lifestyle Intervention on Metabolic Homeostasis in Overweight or Obese Chinese Population
Source: ClinicalTrials.gov · Last updated 9 Feb 2026
Brief summary (registry, in English)
This is an exploratory controlled before-after study, which involves 112 participants, of whom 28 are with normal weight and 84 are overweight or obese. Twelve weeks of caloric-restriction dietary intervention will be conducted in the overweight or obese participants. Before and after the 12-week intervention, metabolic health will be characterized by metabolic homeostasis, determined via comprehensive measurements of dynamic postprandial metabolic responses to a standardized mixed macronutrient tolerance test (75 g glucose, 60 g fat, 20 g protein) in a whole-room indirect calorimeter. The objectives of this study are 1. to characterize dynamic metabolic response elicited by acute nutritional and acute exercise challenges, 2. to elucidate biological mechanisms underlying inter-individual heterogeneity in these responses, 3. to predict prospective weight loss over the intervention using heterogeneous metabolic responses to acute challenges
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 117 (actual)
- First submitted
- 1 Mar 2023
- Start date
- 2 Mar 2023
- Primary completion date
- 1 Mar 2025
- Lead sponsor
- Chinese Academy of Sciences
- Diseases
- Obesity
- NCT number
- NCT05785221
What you commit to
- Study type: Interventional
- Participants enrolled: 117
- From 2 Mar 2023 to the primary completion date, 1 Mar 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of estrogen therapy or hormonal drugs in the preceding 6 months
- Surgical events preceding 1 year (except appendicitis or hernia surgery)
- Cancer or receiving radiotherapy and chemotherapy within 5 years
Other illness
- Blood pressure \> 160/100 mmHg; diagnosed phase II or III hypertension or cannot decrease SBP under 160mmHg after anti-hypertension drugs
- History of alcohol abuse or other substance abuse (Alcohol abuse is defined as regular alcohol consumption \> 40 g/day for females or \> 80 g/day for males)
- Severe renal disease or liver disease
- Severe gastrointestinal diseases
- Severe cardiovascular or cerebrovascular diseases
- Implantation of heart stent or any device containing metal material
- Suffering from AIDS, hepatitis A, hepatitis B and other infectious diseases
- Any mental disorders or current use of antidepressants
Lab values
- Fasting glucose \>7.0mmol/L or diagnosed diabetes or taking insulin or other blood glucose-lowering drugs
- Fasting blood TG≥ 5.7 mmol/L or fasting LDL-C≥ 4.9 mmol/L or cannot control TG \< 5.7 mmol/L or LDL-C \< 4.9 mmol/L after taking lipid lowering drugs
Other
- Pregnant or lactating
- Attempting to change body weight in the past 3 months
- Use of antibiotic in the preceding 3 months for 3-serial days
- Smokers
- Hyperthyroidism or hypothyroidism
- Claustrophobia
- Physical disability
- Cognitive disability
Who the study is looking for
- 20-70 years of age, inclusive
- BMI ≥ 24kg/m2
- Not in other clinical studies currently or in the past three months
Age in the registry: 20 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.