NCT05785871Completed
Hypertension, Brain Clearance, and Markers of Neurodegeneration
Source: ClinicalTrials.gov · Last updated 27 Aug 2025
Brief summary (registry, in English)
The purpose of this research study is to measure cerebrospinal fluid (CSF) clearance in subjects with and without high blood pressure. CSF cushions the brain from impact and carries waste products from the brain to the bloodstream. This process is known as clearance. Impaired removal of proteins from the aging brain causes their buildup and may contribute to an increased risk for Alzheimer's disease. It is also suspected that clearance may be related to the health of vessels carrying the blood throughout the brain. It is known that high blood pressure damages blood vessels and thus may impair clearance. In this project we will examine if having high blood pressure is related to impaired brain clearance and whether treating high blood pressure improves clearance and reduces buildup of Alzheimer's disease-related proteins. Participants will be asked to undergo a medical examination, testing of memory, brain imaging (both magnetic resonance and positron emission tomography, and spinal tap at the beginning of the study and 1 -2 years later.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 80 (actual)
- First submitted
- 14 Mar 2023
- Start date
- 18 Nov 2020
- Primary completion date
- 30 Jun 2025
- Lead sponsor
- Weill Medical College of Cornell University
- Diseases
- High blood pressure
- NCT number
- NCT05785871
What you commit to
- Study type: Observational
- Participants enrolled: 80
- From 18 Nov 2020 to the primary completion date, 30 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Non-essential hypertension
- Diabetes
- Isolated diastolic hypertension
- Neurodegenerative disorders (i.e Parkinson disease)
- Dementia or Mild cognitive impairment at baseline
- Long-life DSM-IV axis 1 disorders
Other
- Long life major depression. Baseline scores greater or equal to 20 on Beck Depression Inventory at baseline
- Mental retardation
- Substance abuse
Who the study is looking for
- Male and female subjects between 60-80 years old
- All subjects will speak English as their first language or demonstrate proficiency in English.
- All subjects will have normal cognition at baseline: a Clinical dementia rating CDR=0, Global deterioration Scale GDS \<2
- For the HTN subjects: systolic HTN defined according to Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood pressure (JNC) 7 report. Specifically: Blood pressure in the ranges greater or equal to 140 mmHG, which is a mean of three seated BP readings on each of two or more office visits
Age in the registry: 60 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Weill Cornell Medicine Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.