NCT05787704Completed
Walking and Thinking - Brain Activity During Complex Walking in People With Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 24 Oct 2024
Brief summary (registry, in English)
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills. However, the process of aging or the sequelae of neurological diseases such as Multiple Sclerosis (MS) compromises motor-cognitive interaction necessary for an independent lifestyle. While motor-cognitive performance has been identified as an important goal for sustained health across different clinical populations, little is known about underlying brain function leading to these difficulties and how to best target these motor-cognitive difficulties in the context of rehabilitation and exercise interventions. The challenge of improving treatments of motor-cognitive difficulties (such as dual-tasking and navigation) is daunting, and an important step is arriving at a method that accurately portrays these impairments in an ecological valid state. The investigators aim therefore to explore brain function during complex walking in MS (in comparison with people with Parkinson's disease and healthy controls) by investigating the effects of neurological disease on motor-cognitive performance and its neural correlates during three conditions of complex walking (dual-task walking, navigation and a combination of both) using non-invasive measures of brain activity (functional near infrared spectrometry, fNIRS) and advanced gait analysis in real time in people with MS (in comparison with people with Parkinson's disease and healthy adults).
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 41 (actual)
- First submitted
- 15 Mar 2023
- Start date
- Apr 2023
- Primary completion date
- May 2024
- Lead sponsor
- Karolinska Institutet
- Diseases
- Multiple sclerosis
- NCT number
- NCT05787704
What you commit to
- Study type: Observational
- Participants enrolled: 41
- From Apr 2023 to the primary completion date, May 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Disease or condition that affects cognition, gait or balance.
- MS relapse or change of disease-modifying treatment within the past eight weeks.
Who the study is looking for
- 18 years or older
- with an MS diagnosis according to McDonald criteria
- with the ability to walk without a mobility device for ≥5 minutes continuously.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Karolinska Institutet Coordinator of this site? Confirm its status | Stockholm | Sweden | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.