NCT05789823CompletedPhase 2
Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-2)
Efficacy and Safety of Ischemic Post-conditioning in Patients With Acute Ischemic Stroke After Mechanical Thrombectomy
Source: ClinicalTrials.gov · Last updated 21 Oct 2026
Brief summary (registry, in English)
Ischemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke. The investigators have conducted a 3 + 3 dose-escalation trial to demonstrate the safety and tolerability of ischemic post-conditioning incrementally for a longer duration of up to 5 min × 4 cycles in stroke patients undergoing mechanical thrombectomy. The purpose of this study is to further determine the efficacy and safety of ischemic post-conditioning in patients with acute ischemic stroke who are treated with mechanical thrombectomy.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 160 (actual)
- First submitted
- 16 Mar 2023
- Start date
- 1 Nov 2023
- Primary completion date
- 16 May 2026
- Lead sponsor
- Capital Medical University
- Diseases
- Stroke
- NCT number
- NCT05789823
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 160
- From 1 Nov 2023 to the primary completion date, 16 May 2026
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- \> 2 times of balloon dilations as rescue therapy due to angioplasty during thrombectomy;
Other illness
- Complications related to thrombectomy, such as contrast agent extravasation, vascular perforation/rupture, dissection, and escape of thrombus;
- Other conditions that the investigator considered inappropriate for inclusion.
Other
- Confirmed or clinically suspected cerebral vasculitis/fibromuscular dysplasia;
- Difficulty in reaching the designated position of the balloon used for ischemic post-conditioning;
- Stenting in the middle cerebral artery M1 segment/distal intracranial carotid artery during thrombectomy;
- Patients with contraindications to MRI;
Who the study is looking for
- Age ≥ 18 years;
- Acute ischemic stroke within 24 hours from stroke onset (or from time last known well) to groin puncture;
- Previous mRS ≤ 2;
- Baseline NIHSS ≥ 6;
- Baseline ASPECTS ≥ 6;
- Unilateral middle cerebral artery occlusion with or without ipsilateral internal carotid artery occlusion;
- Successful recanalization after mechanical thrombectomy (eTICI 2b-3);
- Written informed consent provided by the patients or their legal relatives.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Hospital of Jilin University Coordinator of this site? Confirm its status | Changchun | China | Unknown status |
| Tianjin Fifth Central Hospital Coordinator of this site? Confirm its status | Tianjin | China | Unknown status |
| Tianjin Huanhu Hospital Coordinator of this site? Confirm its status | Tianjin | China | Unknown status |
| The Second Hospital of Tianjin Medical University Coordinator of this site? Confirm its status | Tianjin | China | Unknown status |
| Qinghe people's hospital Coordinator of this site? Confirm its status | Xingtai | China | Unknown status |
| Xingtai central hospital Coordinator of this site? Confirm its status | Xingtai | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.